Journal of Biomedical and Translational Research

About Journal of Biomedical and Translational Research

Journal of Biomedical and Translational Research is the official journal of Research Institute of Veterinary Medicine, Chungbuk National University. Abbreviated title is 'J. Biomed. Transl. Res.'. It was launched in 2000. It contains reviews, original articles, short communications, and case reports, etc, which generally contain overall review on current research issues, results of novel experiment or investigation, rapid publication for research results, examination of clinical cases, and unique experimental procedures or techniques, respectively. It is published only online quarterly in March 31, June 30, September 30 and December 31 each year. Supplement numbers are times published. All of the manuscripts are peer-reviewed.
Original Article

Nov 30, -0001

Effect of inhaled 1,2-dichlorobenzene on cytochrome P450s and lipid peroxidation in B6C3F1 mice

Eun-Sang Cho, Yong-Soon Kim, Hye-yeon Choi, Kyung-Taek Rim

J Biomed Transl Res 2023;24(3):67-82.
https://doi.org/10.12729/jbtr.2023.24.3.67

1,2-Dichlorobenzene (1,2-DCB) is in various industries as solvents in herbicides, pesticides, and wax, and as degreasers or in the production of dyes. Studies on the hazards and risks of 1,2-DCB showed that this substance can cause skin corrosion, skin irritability, respiratory irritability, and certain target organ toxicity. Industrial workers are exposed to 1,2-DCB by inhalation or skin exposure and there is a lack of information on human hazards even though they can be exposed to organic compounds such as benzene or other DCB complexes rathe...
Original Article

Nov 30, -0001

Assessment of single oral dose toxicity of collagen peptide from skate (Raja kenojei) skin

Heung-Sik Seo, Myeong-Kyu Park, Nak-Won Seong, Geun-Hee Kang, Sang-Ho Kim, Joong-Sun Kim, Sung-Ho Kim, Jong-Choon Kim, Changjong Moon

J Biomed Transl Res 2023;24(3):83-92.
https://doi.org/10.12729/jbtr.2023.24.3.83

Collagen peptides have garnered significant attention as functional foods across multiple fields due to their capacity to regulate physiological and hormonal processes, offering numerous advantages. However, despite their broad range of applications, comprehensive research on the potential toxicity of these substances remains lacking. Therefore, this study sought to assess the acute oral toxicity of a collagen peptide derived from skate (Raja kenojei) skin (CPSS) in both rats and dogs. In the rat model, CPSS was orally administ...
Case Report

Nov 30, -0001

A case of transient diabetes mellitus in a dog managed by ovariohysterectomy

YeSeul Jeon, Hyeona Bae, DoHyeon Yu

J Biomed Transl Res 2023;24(3):93-99.
https://doi.org/10.12729/jbtr.2023.24.3.93

A 12-year-old intact female Schnauzer was referred for the evaluation of poorly controlled diabetes mellitus: despite insulin therapy, blood glucose concentration was consistently high, indicating a decreased insulin sensitivity. Laboratory analyses revealed persistent hyperglycemia, glucosuria, and ketonuria. Diagnostic approaches were performed to identify concurrent disorders that can cause insulin resistance. The dog was found to have concurrent hyperadrenocorticism, hyperlipidemia, pancreatitis, and vaginal cytology indicating diestrus in ...
Case Report

Nov 30, -0001

Unusual case of multifocal cerebral infarction in a patient with gastric mucosa-associated lymphoid tissue lymphoma

Hee-Yun Chae, Jeungwan Han, Kyu Sun Yum, Sung-Hyun Lee, Sang-Soo Lee, Jinhyun Kim, Ho-Seong Han, Dong-Ick Shin

J Biomed Transl Res 2023;24(3):101-104.
https://doi.org/10.12729/jbtr.2023.24.3.101

Mucosa-associated lymphoid tissue (MALT) lymphoma (ML) is a type of non-Hodgkin’s lymphoma involving MALT, commonly the stomach or salivary glands, although virtually any mucosal site can be affected. ML originates from B cells in the marginal zone of MALT, and is also called extranodal marginal zone B cell lymphoma. It is a slow-growing cancer that usually responds well to treatment. A 59-year-old female presented with a 1-day history of quadriparesis and dysarthria. Up arrival at the hospital, motor power in the right upper and lower extrem...
Case Report

Nov 30, -0001

Unsuccessful treatment of granulomatous meningoencephalomyelitis in a dog with the combination of multiple immunosuppressive agents

Heetae Park, Jeongmin Lee, Jinyoung Kim, Kunho Song, Joonghyun Song

J Biomed Transl Res 2023;24(3):105-110.
https://doi.org/10.12729/jbtr.2023.24.3.105

A one-year-old, female, Maltese dog was presented with head tilting, horizontal nystagmus, and tetraparesis. Blindness was first identified, and magnetic resonance imaging (MRI) scanning revealed diffuse lesion which was hyperintense on T2-weighted image over the cerebellum and brainstem. The immunosuppressive therapy had been administered, but the patient had no improvement. Re-performed MRI revealed the progression of the pre-existed inflammatory lesions. Treatment with prednisolone, leflunomide, cyclosporine, and cytosine arabinoside was ini...
Case Report

Nov 30, -0001

Clinical application of capsule endoscopy in a dog with acute hemorrhagic vomiting

Hyeona Bae, Dong-In Jung

J Biomed Transl Res 2023;24(3):111-116.
https://doi.org/10.12729/jbtr.2023.24.3.111

A 14-year-old castrated male Shih Tzu presented with acute hemorrhagic vomiting. The initial medical records indicated a probable diagnosis of acute gastritis due to inappropriate food intake. Although gastrointestinal (GI) endoscopy was the preferred diagnostic approach, the client declined anesthesia because of the dog’s underlying heart condition. Therefore, we opted for anesthesia-free capsule endoscopy. The procedure identified severe gastritis with no detectable abnormalities in the other GI regions. Following diagnosis, dietary modific...

CURRENT ISSUE
MOST READ ARTICLE

CURRENT ISSUE: Sep 2023, Vol. 24 , No. 3

Original Article Effect of inhaled 1,2-dichlorobenzene on cytochrome P450s and lipid peroxidation in B6C3F1 mice Eun-Sang Cho, Yong-Soon Kim, Hye-yeon Choi, Kyung-Taek Rim J Biomed Transl Res 2023;24(3):67-82. https://doi.org/10.12729/jbtr.2023.24.3.67 HTML PDF PubReader	Original Article Assessment of single oral dose toxicity of collagen peptide from skate (Raja kenojei) skin Heung-Sik Seo, Myeong-Kyu Park, Nak-Won Seong, Geun-Hee Kang, Sang-Ho Kim, Joong-Sun Kim, Sung-Ho Kim, Jong-Choon Kim, Changjong Moon J Biomed Transl Res 2023;24(3):83-92. https://doi.org/10.12729/jbtr.2023.24.3.83 HTML PDF PubReader
Case Report A case of transient diabetes mellitus in a dog managed by ovariohysterectomy YeSeul Jeon, Hyeona Bae, DoHyeon Yu J Biomed Transl Res 2023;24(3):93-99. https://doi.org/10.12729/jbtr.2023.24.3.93 HTML PDF PubReader	Case Report Unusual case of multifocal cerebral infarction in a patient with gastric mucosa-associated lymphoid tissue lymphoma Hee-Yun Chae, Jeungwan Han, Kyu Sun Yum, Sung-Hyun Lee, Sang-Soo Lee, Jinhyun Kim, Ho-Seong Han, Dong-Ick Shin J Biomed Transl Res 2023;24(3):101-104. https://doi.org/10.12729/jbtr.2023.24.3.101 HTML PDF PubReader
Case Report Unsuccessful treatment of granulomatous meningoencephalomyelitis in a dog with the combination of multiple immunosuppressive agents Heetae Park, Jeongmin Lee, Jinyoung Kim, Kunho Song, Joonghyun Song J Biomed Transl Res 2023;24(3):105-110. https://doi.org/10.12729/jbtr.2023.24.3.105 HTML PDF PubReader	Case Report Clinical application of capsule endoscopy in a dog with acute hemorrhagic vomiting Hyeona Bae, Dong-In Jung J Biomed Transl Res 2023;24(3):111-116. https://doi.org/10.12729/jbtr.2023.24.3.111 HTML PDF PubReader

MOST READ ARTICLE

Case Report Clindamycin-doxycycline-metronidazole combination therapy in a refractory canine babesiosis case Hyung-Mo An, Joong-Hyun Song, Su-Jin An, DoHyeon Yu, Donghyun Han, Young Joo Kim, Dong-In Jung J Biomed Transl Res 2019;20(3):71-74. https://doi.org/10.12729/jbtr.2019.20.3.071 HTML PDF PubReader Last 3 months views: 1045	Original Article Echocardiographic evaluation of heart failure in dogs with myxomatous mitral valve disease: a retrospective study Donghyun Han, Dong-Guk Lee, Dong-In Jung J Biomed Transl Res 2018;19(4):79-85. https://doi.org/10.12729/jbtr.2018.19.4.079 HTML PDF PubReader Last 3 months views: 621
ARTICLE Probiotic dietary supplementation in a dog with chronic kidney disease Sookrang Jo, Minhee Kang, Kyoim Lee, Changmin Lee, Seunggon Kim, Sungjae Park, Taewoo Kim, Heemyung Park J Biomed Res 2014;15(1):40-43. https://doi.org/10.12729/jbr.2014.15.1.040 HTML PDF PubReader Last 3 months views: 504	Case report Hematometra in a young Poongsan dog with continuous vulvar hemorrhage Hyun-Sik Kim, Ill-Hwa Kim, Hyun-Gu Kang J Biomed Transl Res 2016;17(4):121-125. https://doi.org/10.12729/jbtr.2016.17.4.121 HTML PDF PubReader Last 3 months views: 501
Case report Effective treatment of eosinophilic granuloma in a cat using tacrolimus with prednisolone Min-young Moon, Guk-Hyun Suh, Yong-Jin Kwon, Ha-Jung Kim J Biomed Transl Res 2017;18(3):118-120. https://doi.org/10.12729/jbtr.2017.18.3.118 HTML PDF PubReader Last 3 months views: 417	Case Report Prednisolone-induced diabetes mellitus without pancreatic islet pathology in a dog Taesik Yun, Hakhyun Kim, Yoonhoi Koo, Dongwoo Chang, Byeong-Teck Kang, Mhan-Pyo Yang J Biomed Transl Res 2021;22(1):63-69. https://doi.org/10.12729/jbtr.2021.22.1.063 HTML PDF PubReader Last 3 months views: 412
Case report Clinical application of dapsone in two cases of canine sterile nodular panniculitis Sun-Hwa Kim, Sun-Hyung Cho, Ji-Houn Kang, Mhan-Pyo Yang, In-Pil Mo, Byeong-Teck Kang J Biomed Transl Res 2016;17(4):115-120. https://doi.org/10.12729/jbtr.2016.17.4.115 HTML PDF PubReader Last 3 months views: 382	Original Article Retrospective study of 23 dogs with meningoencephalomyelitis of unknown etiology Jun-Hee Kim, Mhan-Pyo Yang, Hakhyun Kim, Jeeyun Kim, Sijin Cha, Dohee Lee, Yeon Chae, Taesik Yun, Yoonhoi Koo, Byeong-Teck Kang J Biomed Transl Res 2022;23(4):203-214. https://doi.org/10.12729/jbtr.2022.23.4.203 HTML PDF PubReader Last 3 months views: 363