Journal of Biomedical and Translational Research

About Journal of Biomedical and Translational Research

Journal of Biomedical and Translational Research is the official journal of Research Institute of Veterinary Medicine, Chungbuk National University. Abbreviated title is 'J. Biomed. Transl. Res.'. It was launched in 2000. It contains reviews, original articles, short communications, and case reports, etc, which generally contain overall review on current research issues, results of novel experiment or investigation, rapid publication for research results, examination of clinical cases, and unique experimental procedures or techniques, respectively. It is published only online quarterly in March 31, June 30, September 30 and December 31 each year. Supplement numbers are times published. All of the manuscripts are peer-reviewed.
Review Article

Nov 30, -0001

Functions of flavonoids in three Korean native varieties of Artemisia species

Hun Hwan Kim, Preethi Vetrivel, Sang Eun Ha, Pritam Bhagwan Bhosale, Ho Jeong Lee, Jin-A Kim, Kwang Il Park, Seong Min Kim, Gon Sup Kim

J Biomed Transl Res 2020;21(2):39-49.
https://doi.org/10.12729/jbtr.2020.21.2.039

The development of drugs from natural plant sources is at growing interest due to the limitations of chemical drugs in terms of side effects and cost-effective factors of natural medicines. Among the various components contained in natural plant materials, flavonoids are of increasing interest because of their extended biological benefits. Flavonoids are classified into various types according to their structure and possess different activities depending on the structure. In this study, the flavonoids contained in Artemisia, na...
Review Article

Nov 30, -0001

Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms

Pritam Bhagwan Bhosale, Sang Eun Ha, Preethi Vetrivel, Hun Hwan Kim, Jin-A Kim, Kwang-Il Park, Seong Min Kim, Gon Sup Kim

J Biomed Transl Res 2020;21(2):50-58.
https://doi.org/10.12729/jbtr.2020.21.2.050

Cancer is the second leading cause of death worldwide and currently there are many approaches developing towards cancer treatment. Cancer treatments like chemotherapy and radiation therapy are often painful and have adverse effects. The mechanism of apoptosis is a complex process and it involves different pathways in its mechanism of action. Apoptosis can be caused by signals within the cell such as stress, or by extrinsic signals such as ligands binding to cell surface death receptors. The programmed cell death plays a important role in the se...
Research Article

Nov 30, -0001

Artemisia annua extract ameliorates high-fat diet-induced fatty liver by activating AMPK

Su-Jin Park, Chul Yung Choi, Jae-Cheon Jeong, Rok-Kyoung Lee, Yong-Pil Hwang

J Biomed Transl Res 2020;21(2):59-71.
https://doi.org/10.12729/jbtr.2020.21.2.059

Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in industrialized countries. Recently, natural compounds that may be beneficial for improving NAFLD have received increasing attention. Artemisia annua L. is the source of antimalarial phytomolecule, artemisinin, which has been reported to prevent obesity. However, the effect of A. annua extract on hepatic lipid metabolism remains unclear. This study was performed to determine the protective effect of Artemisia annua<...
Research Article

Nov 30, -0001

Correlation between carcass grade and progesterone receptor membrane component 1 in Korean Hanwoo

Sang Ryeol Lee, Chang Yeon Kim, Young Ho Lee, Jong-ho Kim, Si-yun Ryu, Bae-keun Park, Eui-Ju Hong

J Biomed Transl Res 2020;21(2):72-78.
https://doi.org/10.12729/jbtr.2020.21.2.072

Carcass grade primarily depends on marbling of intramuscular fat, which is associated with the texture and tenderness of beef. Accordingly, various economical molecular tests for high intramuscular fat in beef have been attempted. Especially, Hanwoo (Korean Cattle) intramuscular fat has higher levels of monounsaturated fatty acids than that in the beef of other cattle. Intramuscular fats are associated with levels of lipid metabolic genes in the liver transcriptome. Therefore, hepatic triglyceride synthesis can considerably increase intramuscul...
Research Article

Nov 30, -0001

Radioisotope-ADME studies of Trastuzumab-monomethyl auristatin F in tumor bearing mice and healthy marmosets

Hye Won Lee, Yun-Hee Park, Sang Hyun Park, Muhammad Asim Raza, Jung Ae Kang, A-Ram Yu, Jae Jun Lee, Jin Ah Hwang, Yun Ha Jeong, Dong Hwan Kim

J Biomed Transl Res 2020;21(2):79-90.
https://doi.org/10.12729/jbtr.2020.21.2.079

Radioisotope ADME (RI-ADME) studies are enabling visualization of the biodistribution in molecular imaging. We applied RI-ADME to investigate the tumor targeting capacity and biodistribution of trastuzumab-monomethyl auristatin F (LCB14-0110) in JIMT-1 xenograft mice and healthy marmoset. The LCB14-0110 was labelled with ¹²⁵I. ¹²⁵I-LCB14-0110 was intravenously administered to the animals. The gamma-count and single-photon emission computed tomography/computed tomography (SPECT/CT) was conducted for biodistributioon and bio...
Case Report

Nov 30, -0001

Prognosis and outcomes of forelimb amputation in two raccoon dogs

Dongwook Kim, Ki-Jeong Na, Gonhyung Kim

J Biomed Transl Res 2020;21(2):91-94.
https://doi.org/10.12729/jbtr.2020.21.2.091

Limb amputation is a salvage surgical procedure relatively common in small animals and other species. Wild animals after forelimb amputation have many difficulties in returning to normal life because forelimbs of arboreal quadrupeds are used to carry most of their weight and hold feed. This study investigated forelimb amputation and its outcomes in two raccoon dogs. Two male raccoon dogs presented for radio-ulnar fractures. Shoulder disarticulation amputation was applied to protect the thoracic cavity and reduce surgical time. After the operati...
Short Communication

Nov 30, -0001

Exploration of the developmental process of vasculogenic mimicry in canine inflammatory mammary carcinoma

Ji-Su Choi, Ye-In Oh, Byung-Woo Lee, Hyun-Wook Kim, Byung-Il Yoon

J Biomed Transl Res 2020;21(2):95-99.
https://doi.org/10.12729/jbtr.2020.21.2.095

Canine inflammatory mammary carcinoma (CIMC) similar to human inflammatory breast cancer is a very aggressive, metastatic type of cancer. Previous studies have introduced a new type of tumor angiogenesis called vasculogenic mimicry that may play an important role in the progression of inflammatory mammary cancer. The purpose of this study is to investigate the development process of vessels by neoplastic cells in CIMC. Patient dog, 14-year old Shit-Tzu female, had a hard and somewhat movable dark-reddish mammary tumor, sized 6.2 cm in diameter....

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CURRENT ISSUE: Jul 2020, Vol. 21 , No. 2

Review Article Functions of flavonoids in three Korean native varieties of Artemisia species Hun Hwan Kim, Preethi Vetrivel, Sang Eun Ha, Pritam Bhagwan Bhosale, Ho Jeong Lee, Jin-A Kim, Kwang Il Park, Seong Min Kim, Gon Sup Kim J Biomed Transl Res 2020;21(2):39-49. https://doi.org/10.12729/jbtr.2020.21.2.039 HTML PDF PubReader	Review Article Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms Pritam Bhagwan Bhosale, Sang Eun Ha, Preethi Vetrivel, Hun Hwan Kim, Jin-A Kim, Kwang-Il Park, Seong Min Kim, Gon Sup Kim J Biomed Transl Res 2020;21(2):50-58. https://doi.org/10.12729/jbtr.2020.21.2.050 HTML PDF PubReader
Research Article Artemisia annua extract ameliorates high-fat diet-induced fatty liver by activating AMPK Su-Jin Park, Chul Yung Choi, Jae-Cheon Jeong, Rok-Kyoung Lee, Yong-Pil Hwang J Biomed Transl Res 2020;21(2):59-71. https://doi.org/10.12729/jbtr.2020.21.2.059 HTML PDF PubReader	Research Article Correlation between carcass grade and progesterone receptor membrane component 1 in Korean Hanwoo Sang Ryeol Lee, Chang Yeon Kim, Young Ho Lee, Jong-ho Kim, Si-yun Ryu, Bae-keun Park, Eui-Ju Hong J Biomed Transl Res 2020;21(2):72-78. https://doi.org/10.12729/jbtr.2020.21.2.072 HTML PDF PubReader
Research Article Radioisotope-ADME studies of Trastuzumab-monomethyl auristatin F in tumor bearing mice and healthy marmosets Hye Won Lee, Yun-Hee Park, Sang Hyun Park, Muhammad Asim Raza, Jung Ae Kang, A-Ram Yu, Jae Jun Lee, Jin Ah Hwang, Yun Ha Jeong, Dong Hwan Kim J Biomed Transl Res 2020;21(2):79-90. https://doi.org/10.12729/jbtr.2020.21.2.079 HTML PDF PubReader	Case Report Prognosis and outcomes of forelimb amputation in two raccoon dogs Dongwook Kim, Ki-Jeong Na, Gonhyung Kim J Biomed Transl Res 2020;21(2):91-94. https://doi.org/10.12729/jbtr.2020.21.2.091 HTML PDF PubReader
Short Communication Exploration of the developmental process of vasculogenic mimicry in canine inflammatory mammary carcinoma Ji-Su Choi, Ye-In Oh, Byung-Woo Lee, Hyun-Wook Kim, Byung-Il Yoon J Biomed Transl Res 2020;21(2):95-99. https://doi.org/10.12729/jbtr.2020.21.2.095 HTML PDF PubReader

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Original Article Development and validation of LC-MS/MS for bioanalysis of hydroxychloroquine in human whole blood Jung Youl Park, Hyun Ho Song, Young Ee Kwon, Seo Jin Kim, Sukil Jang, Seong Soo Joo J Biomed Transl Res 2018;19(4):130-139. https://doi.org/10.12729/jbtr.2018.19.4.130 HTML PDF PubReader Last 3 months views: 220	Original Article Anti-inflammatory activities of sinensetin on LPS-stimulated L6 skeletal muscle cells Jin-A Kim, Sang Eun Ha, Seong Min Kim, Preethi Vetrivel, Gon Sup Kim, Eun Hee Kim J Biomed Transl Res 2019;20(1):1-7. https://doi.org/10.12729/jbtr.2019.20.1.001 HTML PDF PubReader Last 3 months views: 219
Review Selectins: functional importance as cell adhesion molecule in immune system Yunjeong Noh, Donghyun Cho, Haesu Ko, Dajeong Lim, Han-Ha Chai J Biomed Transl Res 2019;20(4):75-81. https://doi.org/10.12729/jbtr.2019.20.4.075 HTML PDF PubReader Last 3 months views: 211	Original Article Prevention or treatment of enzyme treated royal jelly on monosodium-iodoacetate-induced osteoarthritis Sun Hwa Hong, Sung Woo Hwang, Yeon Kyung Son, Na Young Lee, Okjin Kim J Biomed Transl Res 2020;21(1):1-10. https://doi.org/10.12729/jbtr.2020.21.1.1 HTML PDF PubReader Last 3 months views: 200
ARTICLE Poria cocos ethanol extract and its active constituent, pachymic acid, modulate sleep architectures via activation of GABA_A-ergic transmission in rats funcVikash Kumar Shah, Sam-Shik Na, Myong-Soo Chong, Jae-Hoon Woo, Yeong-Ok Kwon, Mi Kyeong Lee, Ki-Wan Oh J Biomed Res 2015;16(3):84-92. https://doi.org/10.12729/jbr.2015.16.3.084 HTML PDF PubReader Last 3 months views: 182	Original Article A 13-week repeated dose oral toxicity study on a water extract of Artemisia annua in Sprague-Dawley rat Su-Jin Park, Seong-Hyun Ho, Seon-Hee Kim, Chanyoung Park, Eun-Young Cho, Ji-Ran You J Biomed Transl Res 2020;21(1):30-37. https://doi.org/10.12729/jbtr.2020.21.1.30 HTML PDF PubReader Last 3 months views: 163
Original Article Lysyl oxidase-variant 2 functions as an amine oxidase toward histone H2A Chunying Li, Anjali Sharma-Bhandari, Youngho Kim J Biomed Transl Res 2020;21(1):17-23. https://doi.org/10.12729/jbtr.2020.21.1.17 HTML PDF PubReader Last 3 months views: 161	Original Article Uncertainty of somatosensory evoked potentials during neurosurgical procedure Hoon Kang, Donggeun Lee, Jeongmoon Won J Biomed Transl Res 2019;20(4):105-109. https://doi.org/10.12729/jbtr.2019.20.4.105 HTML PDF PubReader Last 3 months views: 157