Journal of Biomedical and Translational Research

About Journal of Biomedical and Translational Research

Journal of Biomedical and Translational Research is the official journal of Research Institute of Veterinary Medicine, Chungbuk National University. Abbreviated title is 'J. Biomed. Transl. Res.'. It was launched in 2000. It contains reviews, original articles, short communications, and case reports, etc, which generally contain overall review on current research issues, results of novel experiment or investigation, rapid publication for research results, examination of clinical cases, and unique experimental procedures or techniques, respectively. It is published only online quarterly in March 31, June 30, September 30 and December 31 each year. Supplement numbers are times published. All of the manuscripts are peer-reviewed.
Review Article

Nov 30, -0001

Application of artificial intelligence in toxicopathology

Jin Seok Kang

J Biomed Transl Res 2021;22(1):1-11.
https://doi.org/10.12729/jbtr.2021.22.1.1

Traditionally, pathologists examine tissue slides under a microscope to find pathological lesions, and have the burden of finding the lesions among so many histopathology slides. Furthermore, inconsistency of diagnoses results differ corresponding to training among researchers. Therefore, accumulated research experience has led to the use of novel tools for increasing accuracy and consistency of diagnoses. With rapid transition from analog to digital methods and new developments in digital pathology, it is possible to use whole slide imaging (W...
Original Article

Nov 30, -0001

Celecoxib, a selective cyclooxygenase-2 inhibitor, aggravates radiation-induced intestinal damage in mice

Sueun Lee, Jin Mi Chun, Ji Hye Lee, Yun-Soo Seo, Jun Hong Park, Hae-June Lee, Changjong Moon, Sung-Ho Kim, Joong-Sun Kim

J Biomed Transl Res 2021;22(1):12-18.
https://doi.org/10.12729/jbtr.2021.22.1.12

Celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, was approved as a non-steroidal anti-inflammatory drug (NSAID), and this therapeutic application has been expanded to several other diseases, including colon cancer. Notably, a treatment strategy combining the use of celecoxib and radiation therapy has been employed for improving the control of local cancers. In this study, we examined the effect of celecoxib on irradiation-induced intestinal damage. The twenty four mice (BALB/c) were divided into four groups; 1) sham-irradiated control g...
Original Article

Nov 30, -0001

Seroprevalence of rabies virus antibody for dogs and cats in Seoul during 2017–2019

Yoon-Kyung Jeong, Ho-Kyung Sung, Beom Jun Lee

J Biomed Transl Res 2021;22(1):19-25.
https://doi.org/10.12729/jbtr.2021.22.1.19

Rabies is a zoonotic disease that is caused by rabies virus and transmitted only in mammals. Domestic dogs are the most common reservoir of the virus, which is associated with more than 99% human deaths caused by dog-mediated rabies in the world. Rabies is one of the most fatal diseases, but it is fully preventable in animals by vaccination. Serological test of rabies virus antibody for samples collected from dogs and cats in Seoul during 2017–2019 was carried out in this study. To investigate antibody seroprevalence of rabies virus for dogs ...
Original Article

Nov 30, -0001

The effect of pentoxifylline on radiation-induced bone loss in C3H/HeN mice

Sung-Ho Kim

J Biomed Transl Res 2021;22(1):26-31.
https://doi.org/10.12729/jbtr.2021.22.1.26

Developments in cancer therapies and diagnostic techniques have improved the long-term survival of cancer patients. Certain cancer treatments, such as radiotherapy, often harm normal tissue as well as the specifically targeted cancer cells. High doses of radiation induce bone loss. This study investigated the effects of pentoxifylline (PTX) on radiation-induced bone loss in C3H/HeN mice. C3H/HeN mice were divided into sham and irradiation (3 Gy, gamma-ray, IR) groups. The irradiated mice were treated for 12 weeks with vehicle, PTX (p.o.) or PTX...
Original Article

Nov 30, -0001

Effects of Lactobacillus acidophilus HY7032 and Lactobacillus reuteri HY7506 isolated from dog feces on welfare and hair in companion dogs

Hong-Jae Lee, Sang-Won Lee

J Biomed Transl Res 2021;22(1):32-41.
https://doi.org/10.12729/jbtr.2021.22.1.32

Precise combinations of probiotics can be useful in dog nutrition, treatment and care. Also, host specificity must be considered in order to increase the effectiveness of probiotics. In this study, Lactobacillus acidophilus HY7032 and Lactobacillus reuteri HY7506 were used, which were isolated from feces of healthy dogs through the verification of pH, bile salt tolerance, and antibacterial activity. In addition, the selected strains were confirmed for activity in immune cells. Briefly, L. acidophilus
Original Article

Nov 30, -0001

Effects of cadmium on the behavior and regeneration of Dugesia japonica

Yong-Jin Kim, Yeon-Hwa Kim, A. A. Dilki Indrachapa Adikari, Juneno So, Young-Joo Yi, Sang-Myeong Lee

J Biomed Transl Res 2021;22(1):42-48.
https://doi.org/10.12729/jbtr.2021.22.1.42

This study was undertaken to evaluate the toxic effect of cadmium sulfate (Cds) on planarians (Dugesia japonica), and the suitability of planarians as an alternative animal model for toxicity studies. Planarians were exposed to varying concentrations of experimental solutions containing 0.1–25 mg/L Cds, and incubated for 1, 3, and 5 hrs. Motility, seizure-like behaviors (c-like, head-bop, snake-like, and screw-like) and regeneration ability of the amputated fragment were subsequently evaluated. Results showed decreased motili...
Original Article

Nov 30, -0001

Survey and risk assessment on residual pesticides and heavy metals in coffee beans distributed in Daejeon

Daehyun Kim, Sujin Oh, Youngju Song, Sookkyung Shin, Sangjoon Lee, Jeongah Kim, Gunehee Jo, Beom Jun Lee

J Biomed Transl Res 2021;22(1):49-62.
https://doi.org/10.12729/jbtr.2021.22.1.49

The content of harmful materials was investigated for coffee beans sold in Daejeon. Total 79 samples were analysed and 213 residual pesticides and 2 heavy metals were analysed simultaneously by GC-MS/MS, GC-NPD, GC-ECD, LC-MS/MS and ICP-MS. The instrumental method was validated with limit of detection (LOD), limit of quantification (LOQ), the linearity of standard curves. LOD of the residual pesticides was between 0.0003 to 0.0021 mg/kg, LOQ of the residual pesticides was between 0.0008 to 0.0064 mg/kg. LOD of the heavy metals was between 0.007...
Case Report

Nov 30, -0001

Prednisolone-induced diabetes mellitus without pancreatic islet pathology in a dog

Taesik Yun, Hakhyun Kim, Yoonhoi Koo, Dongwoo Chang, Byeong-Teck Kang, Mhan-Pyo Yang

J Biomed Transl Res 2021;22(1):63-69.
https://doi.org/10.12729/jbtr.2021.22.1.63

A one-year-old, intact male Maltese was referred with dehydration, anorexia, and marked hyperglycemia. The dog had been managed due to meningoencephalitis of unknown etiology (MUE) for three months. The dog had been treated with long-term prednisolone administration. Diabetic ketoacidosis (DKA) was identified based on the blood chemistry and venous gas analyses, and intensive treatments including insulin administration were initiated. On further examinations, there was no any other disease that contributed to the occurrence of DKA. Insulin resi...

CURRENT ISSUE
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CURRENT ISSUE: Mar 2021, Vol. 22 , No. 1

Review Article Application of artificial intelligence in toxicopathology Jin Seok Kang J Biomed Transl Res 2021;22(1):1-11. https://doi.org/10.12729/jbtr.2021.22.1.1 HTML PDF PubReader	Original Article Celecoxib, a selective cyclooxygenase-2 inhibitor, aggravates radiation-induced intestinal damage in mice Sueun Lee, Jin Mi Chun, Ji Hye Lee, Yun-Soo Seo, Jun Hong Park, Hae-June Lee, Changjong Moon, Sung-Ho Kim, Joong-Sun Kim J Biomed Transl Res 2021;22(1):12-18. https://doi.org/10.12729/jbtr.2021.22.1.12 HTML PDF PubReader
Original Article Seroprevalence of rabies virus antibody for dogs and cats in Seoul during 2017–2019 Yoon-Kyung Jeong, Ho-Kyung Sung, Beom Jun Lee J Biomed Transl Res 2021;22(1):19-25. https://doi.org/10.12729/jbtr.2021.22.1.19 HTML PDF PubReader	Original Article The effect of pentoxifylline on radiation-induced bone loss in C3H/HeN mice Sung-Ho Kim J Biomed Transl Res 2021;22(1):26-31. https://doi.org/10.12729/jbtr.2021.22.1.26 HTML PDF PubReader
Original Article Effects of Lactobacillus acidophilus HY7032 and Lactobacillus reuteri HY7506 isolated from dog feces on welfare and hair in companion dogs Hong-Jae Lee, Sang-Won Lee J Biomed Transl Res 2021;22(1):32-41. https://doi.org/10.12729/jbtr.2021.22.1.32 HTML PDF PubReader	Original Article Effects of cadmium on the behavior and regeneration of Dugesia japonica Yong-Jin Kim, Yeon-Hwa Kim, A. A. Dilki Indrachapa Adikari, Juneno So, Young-Joo Yi, Sang-Myeong Lee J Biomed Transl Res 2021;22(1):42-48. https://doi.org/10.12729/jbtr.2021.22.1.42 HTML PDF PubReader
Original Article Survey and risk assessment on residual pesticides and heavy metals in coffee beans distributed in Daejeon Daehyun Kim, Sujin Oh, Youngju Song, Sookkyung Shin, Sangjoon Lee, Jeongah Kim, Gunehee Jo, Beom Jun Lee J Biomed Transl Res 2021;22(1):49-62. https://doi.org/10.12729/jbtr.2021.22.1.49 HTML PDF PubReader	Case Report Prednisolone-induced diabetes mellitus without pancreatic islet pathology in a dog Taesik Yun, Hakhyun Kim, Yoonhoi Koo, Dongwoo Chang, Byeong-Teck Kang, Mhan-Pyo Yang J Biomed Transl Res 2021;22(1):63-69. https://doi.org/10.12729/jbtr.2021.22.1.63 HTML PDF PubReader

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Original Article Echocardiographic evaluation of heart failure in dogs with myxomatous mitral valve disease: a retrospective study Donghyun Han, Dong-Guk Lee, Dong-In Jung J Biomed Transl Res 2018;19(4):79-85. https://doi.org/10.12729/jbtr.2018.19.4.079 HTML PDF PubReader Last 3 months views: 253	Research Article Artemisia annua extract ameliorates high-fat diet-induced fatty liver by activating AMPK Su-Jin Park, Chul Yung Choi, Jae-Cheon Jeong, Rok-Kyoung Lee, Yong-Pil Hwang J Biomed Transl Res 2020;21(2):59-71. https://doi.org/10.12729/jbtr.2020.21.2.059 HTML PDF PubReader Last 3 months views: 242
Review Selectins: functional importance as cell adhesion molecule in immune system Yunjeong Noh, Donghyun Cho, Haesu Ko, Dajeong Lim, Han-Ha Chai J Biomed Transl Res 2019;20(4):75-81. https://doi.org/10.12729/jbtr.2019.20.4.075 HTML PDF PubReader Last 3 months views: 238	Original Article Anti-inflammatory activities of sinensetin on LPS-stimulated L6 skeletal muscle cells Jin-A Kim, Sang Eun Ha, Seong Min Kim, Preethi Vetrivel, Gon Sup Kim, Eun Hee Kim J Biomed Transl Res 2019;20(1):1-7. https://doi.org/10.12729/jbtr.2019.20.1.001 HTML PDF PubReader Last 3 months views: 219
Case report Hematometra in a young Poongsan dog with continuous vulvar hemorrhage Hyun-Sik Kim, Ill-Hwa Kim, Hyun-Gu Kang J Biomed Transl Res 2016;17(4):121-125. https://doi.org/10.12729/jbtr.2016.17.4.121 HTML PDF PubReader Last 3 months views: 215	Case Report Clindamycin-doxycycline-metronidazole combination therapy in a refractory canine babesiosis case Hyung-Mo An, Joong-Hyun Song, Su-Jin An, DoHyeon Yu, Donghyun Han, Young Joo Kim, Dong-In Jung J Biomed Transl Res 2019;20(3):71-74. https://doi.org/10.12729/jbtr.2019.20.3.071 HTML PDF PubReader Last 3 months views: 209
Short communication The anti-Influenza effect of a water soluble herbal extract from Salvia miltiorrhiza (Danshen) in vivo Eun-Seo Lee, Myun Soo Kim, Prasanna Weeratunga, Hyun-Cheol Lee, Kiramage Chathuranga, Jin Yeul Ma, Hong Ik Kim, Jong-Soo Lee J Biomed Transl Res 2018;19(1):21-25. https://doi.org/10.12729/jbtr.2018.19.1.021 HTML PDF PubReader Last 3 months views: 198	Review A comprehensive review of hypertrophic cardiomyopathy and arterial thromboembolism in cats Donghyun Han, Dong-In Jung J Biomed Transl Res 2019;20(4):82-90. https://doi.org/10.12729/jbtr.2019.20.4.082 HTML PDF PubReader Last 3 months views: 193