Journal of Biomedical and Translational Research

About Journal of Biomedical and Translational Research

Journal of Biomedical and Translational Research is the official journal of Research Institute of Veterinary Medicine, Chungbuk National University. Abbreviated title is 'J. Biomed. Transl. Res.'. It was launched in 2000. It contains reviews, original articles, short communications, and case reports, etc, which generally contain overall review on current research issues, results of novel experiment or investigation, rapid publication for research results, examination of clinical cases, and unique experimental procedures or techniques, respectively. It is published only online quarterly in March 31, June 30, September 30 and December 31 each year. Supplement numbers are times published. All of the manuscripts are peer-reviewed.
Review Article

Nov 30, -0001

Inflammatory bowel disease pathogenesis mediated by Th17 cells: cytokines, microbiota, and therapies

Ji-Hyun Park, Min Hyeok Lee, Chan-Su Park

J Biomed Transl Res 2024;25(2):15-32.
https://doi.org/10.12729/jbtr.2024.25.2.15

Inflammatory bowel disease (IBD) is a chronic condition characterized by continuous inflammation of the gastrointestinal tract that varies in intensity over time. IBD is caused by several factors including aberrant gut flora, immunological dysregulation, altered environmental conditions, and genetic variations. However, the pathogenesis of IBD remains unclear. Studies have indicated that an imbalance between T helper 17 (Th17) and regulatory T (Treg) cells contributes significantly to the development of IBD. Intestinal Tregs suppress inflammati...
Original Article

Nov 30, -0001

Patents trends analysis of microbiome-based treatment technology for neurological disorders in pets

Byung-Suk Jeon, Huiyeong Jeong, Sohee Jeong, Changjong Moon, Jong-Hwan Park, Sung-Ho Kim, Joong-Sun Kim

J Biomed Transl Res 2024;25(2):33-39.
https://doi.org/10.12729/jbtr.2024.25.2.33

This study was conducted to collect the patents of microbiome-based treatment technology for pets. An electronic search for microbiome or probiotics in brain nervous system disease was studied using the WINTELIPS database. Patent Cooperation Treaty of Korea, Japan, the EU, the US, and China that were registered by October 31, 2022 were selected in this study. A total of 206 patents were included for final analysis. Since 2016, patent activity has shown an explosive increase in recent years. China is the leading market in this technology field, ...
Original Article

Nov 30, -0001

Alteration of goat kids’ gut microbiota by Cryptosporidium parvum infection

Subin Lee, Badriah Alkathiri, Ah-Young Kim, Kyung-Hyo Do, Kwangwon Seo, Soochong Kim, Wan-Kyu Lee, Dongmi Kwak, Seung-Hun Lee

J Biomed Transl Res 2024;25(2):41-52.
https://doi.org/10.12729/jbtr.2024.25.2.41

Caprine cryptosporidiosis mainly occurs in young goats, with morbidity rates of 80%–100% and mortality over 50% in goat kids. However, limited research has been conducted on the impact of Cryptosporidium parvum, a diarrhea-causing pathogen, on the intestinal microbiota of goat kids. In this study, 16S rRNA-based metataxonomic analysis was performed to compare the microbial diversity and abundance of the gut microbiota between C. parvum-infected and uninfected goat kids. In total, 12 goat fecal samples were co...
Original Article

Nov 30, -0001

Comparison of in vitro models for drug-induced liver injury assessment

Nam-Ju Kim, Ji-Hyun Bang, Hee Yi, Hyun-Ok Ku, Joong-Sun Kim, Ji-Yeon Kim, Byung-Suk Jeon

J Biomed Transl Res 2024;25(2):53-67.
https://doi.org/10.12729/jbtr.2024.25.2.53

Drug-induced liver injury (DILI) is considered to be a significant cause of drug wastage. To mitigate clinical DILI risks, assessing drugs using human liver models is crucial since animal studies may fall short due to species-specific liver pathway variations. Cell-based preclinical hepatotoxicity testing is often pertinent. In the present study, cells from a human liver cancer line (HepG2 and HepaRG) were cultured in both formats of 2D and 3D spheroids to explore their responses to drugs. Liver-specific marker expressions across cell lines and...
Original Article

Nov 30, -0001

Single dose oral toxicity study of a water extract of Gekko gecko in Sprague-Dawley rats

Byung-Suk Jeon, Hyeon Hwa Nam, Huiyeong Jeong, Joong-Sun Kim, Sueun Lee, Ji Hye Lee, Yun-Soo Seo

J Biomed Transl Res 2024;25(2):69-77.
https://doi.org/10.12729/jbtr.2024.25.2.69

Traditional medicine and herbal remedies are gaining popularity worldwide, comprising a significant portion of healthcare research, advancements, and market demand. Growing scientific evidence supports their substantial efficacy as pharmaceutical ingredients and dietary supplements in preventive healthcare. When developing pharmaceuticals, it is crucial to ensure that ingredients are free from side effects and toxicity in order to prioritize safety. Geckos, known as shou gong, are a diverse group of lizards that are widely utilized for treating...
Original Article

Nov 30, -0001

Potential use of ashwagandha extract in storage of liquid boar semen

Malavi Arachchi Gamage Nayodya Dananjanee Malavi A Gamage, Wijesooriya Mudhiyanselage Nadeema Dissanayake, Young-Joo Yi

J Biomed Transl Res 2024;25(2):79-88.
https://doi.org/10.12729/jbtr.2024.25.2.79

The functional roles of plant extracts have been investigated for the treatment of various diseases including subfertility. Recent studies have highlighted the benefits of ashwagandha extract (AE) in enhancing sperm production, boosting testosterone levels, and lowering reactive oxygen species (ROS) levels in mammals. The current study is to examine the effects of the addition of AE to liquid boar semen on sperm quality during storage and its potential application in assisted reproductive technology. A hot water extract of ashwagandha was prepa...
Original Article

Nov 30, -0001

Preliminary investigation on antimicrobial uses in small animal clinics in South Korea

Obaidul Islam, Heyong-seok Kim, Jong-Won Kim, Kyung-Duk Min

J Biomed Transl Res 2024;25(2):89-99.
https://doi.org/10.12729/jbtr.2024.25.2.89

Antimicrobial resistance significantly threatens human and animal health globally, with considerable mortality and economic impact. This study investigated antimicrobial usage in small animal clinics in South Korea, focusing on understanding the trends in prescriptions for therapeutic and preventive purposes. Data were collected from 12 small animal clinics that were analyzed for antimicrobial prescriptions from 2018–2020. A comprehensive dataset was used, including patient signalment, clinical notes, and prescription details, and statistical...
Short Communication

Nov 30, -0001

Investigating immunization via the esophagus: carrageenan’s impact on immune activation

Taesaeng Choi

J Biomed Transl Res 2024;25(2):101-106.
https://doi.org/10.12729/jbtr.2024.25.2.101

This study aimed to investigate the effectiveness of carrageenan (CGN) as an oral immune adjuvant. During the initial research, the inadvertent shallow insertion of an oral gavage needle confirmed CGN’s effect as an adjuvant for esophageal immunization. However, in oral immunization, antibody formation was not observed regardless of CGN’s presence or absence as an adjuvant. Conversely, when bovine serum albumin (used as an antigen) was introduced into the esophagus along with CGN, it resulted in the production of antigen-specific IgG. An ex...

CURRENT ISSUE: Jun 2024, Vol. 25 , No. 2

Review Article Inflammatory bowel disease pathogenesis mediated by Th17 cells: cytokines, microbiota, and therapies Ji-Hyun Park, Min Hyeok Lee, Chan-Su Park J Biomed Transl Res 2024;25(2):15-32. https://doi.org/10.12729/jbtr.2024.25.2.15 HTML PDF PubReader	Original Article Patents trends analysis of microbiome-based treatment technology for neurological disorders in pets Byung-Suk Jeon, Huiyeong Jeong, Sohee Jeong, Changjong Moon, Jong-Hwan Park, Sung-Ho Kim, Joong-Sun Kim J Biomed Transl Res 2024;25(2):33-39. https://doi.org/10.12729/jbtr.2024.25.2.33 HTML PDF PubReader
Original Article Alteration of goat kids’ gut microbiota by Cryptosporidium parvum infection Subin Lee, Badriah Alkathiri, Ah-Young Kim, Kyung-Hyo Do, Kwangwon Seo, Soochong Kim, Wan-Kyu Lee, Dongmi Kwak, Seung-Hun Lee J Biomed Transl Res 2024;25(2):41-52. https://doi.org/10.12729/jbtr.2024.25.2.41 HTML PDF PubReader	Original Article Comparison of in vitro models for drug-induced liver injury assessment Nam-Ju Kim, Ji-Hyun Bang, Hee Yi, Hyun-Ok Ku, Joong-Sun Kim, Ji-Yeon Kim, Byung-Suk Jeon J Biomed Transl Res 2024;25(2):53-67. https://doi.org/10.12729/jbtr.2024.25.2.53 HTML PDF PubReader
Original Article Single dose oral toxicity study of a water extract of Gekko gecko in Sprague-Dawley rats Byung-Suk Jeon, Hyeon Hwa Nam, Huiyeong Jeong, Joong-Sun Kim, Sueun Lee, Ji Hye Lee, Yun-Soo Seo J Biomed Transl Res 2024;25(2):69-77. https://doi.org/10.12729/jbtr.2024.25.2.69 HTML PDF PubReader	Original Article Potential use of ashwagandha extract in storage of liquid boar semen Malavi Arachchi Gamage Nayodya Dananjanee Malavi A Gamage, Wijesooriya Mudhiyanselage Nadeema Dissanayake, Young-Joo Yi J Biomed Transl Res 2024;25(2):79-88. https://doi.org/10.12729/jbtr.2024.25.2.79 HTML PDF PubReader
Original Article Preliminary investigation on antimicrobial uses in small animal clinics in South Korea Obaidul Islam, Heyong-seok Kim, Jong-Won Kim, Kyung-Duk Min J Biomed Transl Res 2024;25(2):89-99. https://doi.org/10.12729/jbtr.2024.25.2.89 HTML PDF PubReader	Short Communication Investigating immunization via the esophagus: carrageenan’s impact on immune activation Taesaeng Choi J Biomed Transl Res 2024;25(2):101-106. https://doi.org/10.12729/jbtr.2024.25.2.101 HTML PDF PubReader

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