Journal of Biomedical and Translational Research

About Journal of Biomedical and Translational Research

Journal of Biomedical and Translational Research is the official journal of Research Institute of Veterinary Medicine, Chungbuk National University. Abbreviated title is 'J. Biomed. Transl. Res.'. It was launched in 2000. It contains reviews, original articles, short communications, and case reports, etc, which generally contain overall review on current research issues, results of novel experiment or investigation, rapid publication for research results, examination of clinical cases, and unique experimental procedures or techniques, respectively. It is published only online quarterly in March 31, June 30, September 30 and December 31 each year. Supplement numbers are times published. All of the manuscripts are peer-reviewed.
Original Article

Dec 31, 2020

Molecular factors related to skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis

Mudan Cai, Eun Jin Yang

J Biomed Transl Res 2020;21(4):143-151.
https://doi.org/10.12729/jbtr.2020.21.4.143

Amyotrophic lateral sclerosis (ALS) is progressive neurological disease that results in the death of motor neurons in the brain and spinal cord, leading to a decrease in skeletal muscle size and muscle weakness, wasting, or paralysis. Most research on ALS has focused on motor neuron death, and the underlying mechanisms are not well understood. This study examined the molecular mechanisms underlying muscle degeneration. We compared the protein and cytokine profiles of gastrocnemius muscle in ALS model hSOD1^G93A mice at pre-symptomatic...
Original Article

Dec 31, 2020

Reference gene selection for gene expression study in tissues of long-tailed chickens

Yunjeong Noh, Woncheoul Park, Han-Ha Chai, Dajeong Lim

J Biomed Transl Res 2020;21(4):152-164.
https://doi.org/10.12729/jbtr.2020.21.4.152

Quantitative real-time polymerase chain reaction (RT-qPCR) is a rapid and precise method of analysis to quantify the level of gene expression and is widely used in the diagnosis of diseases and quantitative analysis of genes. In RT-qPCR analysis, a reference gene (or housekeeping gene) is used for normalization of experimental results. Since this method of analysis detects a small quantity of the product, it is highly sensitive and it is important for the accuracy and reproducibility of the experiment to select a reference gene suitable for gen...
Original Article

Dec 31, 2020

Rotigotine protects dopaminergic neurons through dopamine D2 receptor against 6-hydroxydopamine

Si-joon Lee, Mun-ki Kim, Chung-kil Won

J Biomed Transl Res 2020;21(4):165-170.
https://doi.org/10.12729/jbtr.2020.21.4.165

Dopamine (DA) receptor (D1 and D2-like receptors) agonists are known to affect expression levels of DA receptors. Rotigotine, a DA D2-like receptor agonist, has been developed for treating Parkinson’s disease (PD). However, its role in PD by acting through DA D2-like receptors has not been fully understood yet. The purpose of this study was to investigate neuroprotective effects of rotigotine through DA D2 and D3 receptors in 6-hydroxydopamine (6-OHDA) induced mouse model of PD. Expression level of tyrosine hydroxylase (TH) was examined using...
Original Article

Dec 31, 2020

Protective effect of stevia plant extract against experimental colon carcinogenesis in mice

Hang min Jo, Eun Young Kim, Wang Young Rhee, Jae-Hwang Jeong, Sang Yoon Nam, Beom Jun Lee

J Biomed Transl Res 2020;21(4):171-176.
https://doi.org/10.12729/jbtr.2020.21.4.171

Globally, colon cancer is increased gradually and known as one of the major causes of cancer death. Stevia, a substitute of sugar, is known to have many components including alpha-tocopherol and anthocyanin etc, as antioxidants. This study’s purpose is to investigate whether stevia plant extract can have a protective effect against colon carcinogenesis induced by azoxymethane (AOM) and dextran sodium sulfate (DSS) in mice. Total 30 male ICR mice were divided into 2 groups; AOM/DSS treatment (control group), AOM/DSS + stevia extract (0.5%, in ...
Original Article

Dec 31, 2020

Effect of ascorbic acid and hemin on experimental colon carcinogenesis in mice

Ye-Seo Jeong, Eun Young Kim, Jae-Hwang Jeong, Sang Yoon Nam, Beom Jun Lee

J Biomed Transl Res 2020;21(4):177-183.
https://doi.org/10.12729/jbtr.2020.21.4.177

Colon cancer is known as the third most widespread cancer in the world. The interaction of heme-iron and ascorbic acid (AA) in colon carcinogenesis is not evident. Hemin (ferric chloride heme) is an iron-containing porphyrin with chlorine that can be formed from a heme group. The purpose of this study was to investigate the protective effect of AA on the formation of pre-neoplastic lesions induced by azoxymethane (AOM)/dextran sodium sulfate (DSS) plus hemin in mice. Forty-five ICR male mice were divided into three experimental groups; AOM/ DSS...
Original Article

Dec 31, 2020

Effects of microcystin on the motility of planarians

Young-Joo Yi, Yeon-Hwa Kim, A. A. Dilki Indrachapa Adikari, Seung-Tae Moon, Sang-Myeong Lee

J Biomed Transl Res 2020;21(4):184-189.
https://doi.org/10.12729/jbtr.2020.21.4.184

Cyanobacteria (blue green algae) blooms formed in natural water resources due to the environmental pollution produce toxic compounds as secondary metabolites, causing health hazards to both humans and other living beings. Microcystin is a well-known toxin produced by cynobacteria. The present study was undertaken to evaluate varying concentrations and exposure times of two different forms of microcystin, viz., -LR (MCLR) and -LA (MCLA), on the motility and seizure-like behavior of planarian (Dugesia japonica). Compared to contr...
Review Article

Dec 31, 2020

Coronavirus disease 2019 as a systemic disease: a review

Hoon Kang, Donggeun Lee, Jinsol Lee

J Biomed Transl Res 2020;21(4):190-199.
https://doi.org/10.12729/jbtr.2020.21.4.190

Since a cluster of pneumonia cases of unknown etiology was first reported in China in December 2019, the number of confirmed cases with coronavirus disease 2019 (COVID-19) (caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) worldwide has been increasing, and nearly two million patients are expected to have died by February 2021. Globally, COVID-19 is being considered a primary pulmonary disease, but it is more than a lung infection. This is because patients infected with SARS-CoV-2 present with a variety of clinical signs a...
Case Report

Dec 31, 2020

Massive human Q fever outbreak from a goat farm in Korea

Hyeon Seop Byeon, Bo Young Jeon, Hye Won Jeong, Chang Seop Kim, Rae Hoon Jang, Shin Seok Kang, Mun Hui Chae, Seong Tae Han, Mi Na Han, Byeongwoo Ahn

J Biomed Transl Res 2020;21(4):200-206.
https://doi.org/10.12729/jbtr.2020.21.4.200

We report a massive outbreak of human Q fever cases, which occurred at totally 11 humans. The occurrence was related to a goat farm where Coxiella burnetii infection was diagnosed from goat tissues and environmental specimens. From January of 2018, continuous abortions from 6 goats occurred. Laboratory tests from 77 goat specimens for C. burnetii showed that 54 (70.1%) and 63 (81.8%) goats were positive by polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The infection...

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CURRENT ISSUE: Dec 2020, Vol. 21 , No. 4

Original Article Molecular factors related to skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis Mudan Cai, Eun Jin Yang J Biomed Transl Res 2020;21(4):143-151. https://doi.org/10.12729/jbtr.2020.21.4.143 HTML PDF PubReader	Original Article Reference gene selection for gene expression study in tissues of long-tailed chickens Yunjeong Noh, Woncheoul Park, Han-Ha Chai, Dajeong Lim J Biomed Transl Res 2020;21(4):152-164. https://doi.org/10.12729/jbtr.2020.21.4.152 HTML PDF PubReader
Original Article Rotigotine protects dopaminergic neurons through dopamine D2 receptor against 6-hydroxydopamine Si-joon Lee, Mun-ki Kim, Chung-kil Won J Biomed Transl Res 2020;21(4):165-170. https://doi.org/10.12729/jbtr.2020.21.4.165 HTML PDF PubReader	Original Article Protective effect of stevia plant extract against experimental colon carcinogenesis in mice Hang min Jo, Eun Young Kim, Wang Young Rhee, Jae-Hwang Jeong, Sang Yoon Nam, Beom Jun Lee J Biomed Transl Res 2020;21(4):171-176. https://doi.org/10.12729/jbtr.2020.21.4.171 HTML PDF PubReader
Original Article Effect of ascorbic acid and hemin on experimental colon carcinogenesis in mice Ye-Seo Jeong, Eun Young Kim, Jae-Hwang Jeong, Sang Yoon Nam, Beom Jun Lee J Biomed Transl Res 2020;21(4):177-183. https://doi.org/10.12729/jbtr.2020.21.4.177 HTML PDF PubReader	Original Article Effects of microcystin on the motility of planarians Young-Joo Yi, Yeon-Hwa Kim, A. A. Dilki Indrachapa Adikari, Seung-Tae Moon, Sang-Myeong Lee J Biomed Transl Res 2020;21(4):184-189. https://doi.org/10.12729/jbtr.2020.21.4.184 HTML PDF PubReader
Review Article Coronavirus disease 2019 as a systemic disease: a review Hoon Kang, Donggeun Lee, Jinsol Lee J Biomed Transl Res 2020;21(4):190-199. https://doi.org/10.12729/jbtr.2020.21.4.190 HTML PDF PubReader	Case Report Massive human Q fever outbreak from a goat farm in Korea Hyeon Seop Byeon, Bo Young Jeon, Hye Won Jeong, Chang Seop Kim, Rae Hoon Jang, Shin Seok Kang, Mun Hui Chae, Seong Tae Han, Mi Na Han, Byeongwoo Ahn J Biomed Transl Res 2020;21(4):200-206. https://doi.org/10.12729/jbtr.2020.21.4.200 HTML PDF PubReader

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Original Article Echocardiographic evaluation of heart failure in dogs with myxomatous mitral valve disease: a retrospective study Donghyun Han, Dong-Guk Lee, Dong-In Jung J Biomed Transl Res 2018;19(4):79-85. https://doi.org/10.12729/jbtr.2018.19.4.079 HTML PDF PubReader Last 3 months views: 278	Review Selectins: functional importance as cell adhesion molecule in immune system Yunjeong Noh, Donghyun Cho, Haesu Ko, Dajeong Lim, Han-Ha Chai J Biomed Transl Res 2019;20(4):75-81. https://doi.org/10.12729/jbtr.2019.20.4.075 HTML PDF PubReader Last 3 months views: 270
Original Article Melia azedarach extract exhibits a broad spectrum of antiviral effect in vitro and in vivo N. A. Nadeeka Nethmini, Myun Soo Kim, Kiramage Chathuranga, Jin Yeul Ma, Hongik Kim, Jong-Soo Lee J Biomed Transl Res 2020;21(3):125-136. https://doi.org/10.12729/jbtr.2020.21.3.125 HTML PDF PubReader Last 3 months views: 266	Review A comprehensive review of hypertrophic cardiomyopathy and arterial thromboembolism in cats Donghyun Han, Dong-In Jung J Biomed Transl Res 2019;20(4):82-90. https://doi.org/10.12729/jbtr.2019.20.4.082 HTML PDF PubReader Last 3 months views: 229