Journal of Biomedical and Translational Research

About Journal of Biomedical and Translational Research

Journal of Biomedical and Translational Research is the official journal of Research Institute of Veterinary Medicine, Chungbuk National University. Abbreviated title is 'J. Biomed. Transl. Res.'. It was launched in 2000. It contains reviews, original articles, short communications, and case reports, etc, which generally contain overall review on current research issues, results of novel experiment or investigation, rapid publication for research results, examination of clinical cases, and unique experimental procedures or techniques, respectively. It is published only online quarterly in March 31, June 30, September 30 and December 31 each year. Supplement numbers are times published. All of the manuscripts are peer-reviewed.
Original Article

Sep 30, 2021

Comparison of post-operative C-reactive protein levels between elective general and orthopedic surgery in dogs

Mukyung Sung, Dongwook Kim, Wonhyung Choi, Beomju Bae, Sangui Lee, Yawon Hwang, Ki-Jeong Na, Gonhyung Kim

J Biomed Transl Res 2021;22(3):105-110.
https://doi.org/10.12729/jbtr.2021.22.3.105

C-reactive protein (CRP) is an acute-phase protein produced by hepatocytes. The plasma concentration of CRP peaks around 48 hours following stimulation. A rapid decrease in CRP levels is observed when the stimuli end. Considering these characteristics of CRP, it is used to evaluate acute inflammatory responses in clinics. In addition, as it reflects the degree of surgical trauma, measuring the CRP concentration is an effective method of evaluating tissue damage depending upon the surgical method. As CRP is also an acute-phase protein in dogs, t...
Original Article

Sep 30, 2021

Protective effects of folic acid on colon carcinogenesis induced by azoxymethane in mice

Ji Yun Sohn, Eun Young Kim, Jae-Hwang Jeong, Dae Joong Kim, Sang Yoon Nam, Hyun Jik Lee, Beom Jun Lee

J Biomed Transl Res 2021;22(3):111-120.
https://doi.org/10.12729/jbtr.2021.22.3.111

Colon cancer has been considered a leading cause of cancer-associated death. Folic acid is a vitamin necessary for cellular physiological functions and cell viability. However, the association between folic acid intake and colon cancer has been examined in several prospective cohort studies are controversial. This study investigated the effects of folate intake on colon carcinogenesis and oxidative stress in an azoxymethane (AOM)/dextran sodium sulfate (DSS) institute for cancer research (ICR) mouse model. Thirty male ICR mice (5 weeks old) wer...
Original Article

Sep 30, 2021

Electroacupuncture ameliorates blood-brain barrier dysfunction in 5XFAD Alzheimer’s animal model

Mudan Cai, Jun-Hwan Lee, Eun Jin Yang

J Biomed Transl Res 2021;22(3):121-133.
https://doi.org/10.12729/jbtr.2021.22.3.121

Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disease accompanied by aging, followed by memory impairment and cognitive decline. Although numerous attempts have been made to develop treatments for AD, most clinical trials have failed to delay or stop the progression of AD. Electroacupuncture (EA) is a complementary alternative medicine technique widely used to treat pain, inflammation, and neurodegenerative diseases. Additionally, blood-brain barrier (BBB) disruption is a known pathophysiology of neurodegenerat...
Case Report

Sep 30, 2021

Sudden cardiac death as a naturally-occurring ventricular hypertrophy in Macaca fascicularis

Hyeon-Gu Yeo, Keonwoo Kim, Jiyeon Cho, Yu Gyeong Kim, Minji Kim, Jung Bae Seong, Jae-Won Huh, Sung Soo Kim, Youngjeon Lee, Jinyoung Won, Jincheol Seo, Sung-Hyun Park, Junghyung Park, Hyun Kuk Kim, Joo Myung Lee, Bon-Sang Koo, Jeong-Hee An, Chang-Yeop Jeon, You Jung An, Won Seok Choi, Kyung Seob Lim

J Biomed Transl Res 2021;22(3):135-139.
https://doi.org/10.12729/jbtr.2021.22.3.135

Naturally occurring left ventricular hyperplasia is a rare but lethal disease. There are very few reports of this cardiac disease in captive nonhuman primates. In a colony of Macaca mulatta (Rhesus monkey) at California National Primate Research Center, a large number of rhesus macaques were diagnosed by autopsy with naturally occurring left ventricular hypertrophy without obvious underlying diseases over a 22-year period. The confirmatory diagnosis of ventricular hypertrophy was based on findings of notable left ventricular co...
Case Report

Sep 30, 2021

Congestive heart failures caused by myxomatous mitral valve degeneration in a Siberian tiger

Jinsung Park, Jong-uk Kim, Jeongho Kim, Gonhyung Kim, Byeongwoo Ahn

J Biomed Transl Res 2021;22(3):141-147.
https://doi.org/10.12729/jbtr.2021.22.3.141

A 19-year-old male Siberian tiger was presented with inappetence and paralysis of hind limbs. In a computed tomography (CT) scan, intervertebral disk disease at L3–L4 was detected. Cardiac arrest occurred during the surgery. At autopsy, myxomatous mitral valve degeneration (MMVD) and eccentric hypertrophy of the left heart were noted. The diagnosis was congestive heart failure caused by MMVD. Microscopically, myocardial and pulmonary fibrosis were observed in addition to the disintegration of the fibrosa layer and accumulation of glycosaminog...

CURRENT ISSUE
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CURRENT ISSUE: Sep 2021, Vol. 22 , No. 3

Original Article Comparison of post-operative C-reactive protein levels between elective general and orthopedic surgery in dogs Mukyung Sung, Dongwook Kim, Wonhyung Choi, Beomju Bae, Sangui Lee, Yawon Hwang, Ki-Jeong Na, Gonhyung Kim J Biomed Transl Res 2021;22(3):105-110. https://doi.org/10.12729/jbtr.2021.22.3.105 HTML PDF PubReader	Original Article Protective effects of folic acid on colon carcinogenesis induced by azoxymethane in mice Ji Yun Sohn, Eun Young Kim, Jae-Hwang Jeong, Dae Joong Kim, Sang Yoon Nam, Hyun Jik Lee, Beom Jun Lee J Biomed Transl Res 2021;22(3):111-120. https://doi.org/10.12729/jbtr.2021.22.3.111 HTML PDF PubReader
Original Article Electroacupuncture ameliorates blood-brain barrier dysfunction in 5XFAD Alzheimer’s animal model Mudan Cai, Jun-Hwan Lee, Eun Jin Yang J Biomed Transl Res 2021;22(3):121-133. https://doi.org/10.12729/jbtr.2021.22.3.121 HTML PDF PubReader	Case Report Sudden cardiac death as a naturally-occurring ventricular hypertrophy in Macaca fascicularis Hyeon-Gu Yeo, Keonwoo Kim, Jiyeon Cho, Yu Gyeong Kim, Minji Kim, Jung Bae Seong, Jae-Won Huh, Sung Soo Kim, Youngjeon Lee, Jinyoung Won, Jincheol Seo, Sung-Hyun Park, Junghyung Park, Hyun Kuk Kim, Joo Myung Lee, Bon-Sang Koo, Jeong-Hee An, Chang-Yeop Jeon, You Jung An, Won Seok Choi, Kyung Seob Lim J Biomed Transl Res 2021;22(3):135-139. https://doi.org/10.12729/jbtr.2021.22.3.135 HTML PDF PubReader
Case Report Congestive heart failures caused by myxomatous mitral valve degeneration in a Siberian tiger Jinsung Park, Jong-uk Kim, Jeongho Kim, Gonhyung Kim, Byeongwoo Ahn J Biomed Transl Res 2021;22(3):141-147. https://doi.org/10.12729/jbtr.2021.22.3.141 HTML PDF PubReader

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Original Article Echocardiographic evaluation of heart failure in dogs with myxomatous mitral valve disease: a retrospective study Donghyun Han, Dong-Guk Lee, Dong-In Jung J Biomed Transl Res 2018;19(4):79-85. https://doi.org/10.12729/jbtr.2018.19.4.079 HTML PDF PubReader Last 3 months views: 507	Review The potential of earthworm and its components as a therapeutic agent for neuronal damage Byeong Cheol Moon, Joong Sun Kim J Biomed Transl Res 2018;19(3):58-64. https://doi.org/10.12729/jbtr.2018.19.3.058 HTML PDF PubReader Last 3 months views: 503
ARTICLE Probiotic dietary supplementation in a dog with chronic kidney disease Sookrang Jo, Minhee Kang, Kyoim Lee, Changmin Lee, Seunggon Kim, Sungjae Park, Taewoo Kim, Heemyung Park J Biomed Res 2014;15(1):40-43. https://doi.org/10.12729/jbr.2014.15.1.040 HTML PDF PubReader Last 3 months views: 498	Original Article Anti-inflammatory activities of sinensetin on LPS-stimulated L6 skeletal muscle cells Jin-A Kim, Sang Eun Ha, Seong Min Kim, Preethi Vetrivel, Gon Sup Kim, Eun Hee Kim J Biomed Transl Res 2019;20(1):1-7. https://doi.org/10.12729/jbtr.2019.20.1.001 HTML PDF PubReader Last 3 months views: 438
Case Report Clindamycin-doxycycline-metronidazole combination therapy in a refractory canine babesiosis case Hyung-Mo An, Joong-Hyun Song, Su-Jin An, DoHyeon Yu, Donghyun Han, Young Joo Kim, Dong-In Jung J Biomed Transl Res 2019;20(3):71-74. https://doi.org/10.12729/jbtr.2019.20.3.071 HTML PDF PubReader Last 3 months views: 411	Research Article Artemisia annua extract ameliorates high-fat diet-induced fatty liver by activating AMPK Su-Jin Park, Chul Yung Choi, Jae-Cheon Jeong, Rok-Kyoung Lee, Yong-Pil Hwang J Biomed Transl Res 2020;21(2):59-71. https://doi.org/10.12729/jbtr.2020.21.2.059 HTML PDF PubReader Last 3 months views: 395
Case report Hematometra in a young Poongsan dog with continuous vulvar hemorrhage Hyun-Sik Kim, Ill-Hwa Kim, Hyun-Gu Kang J Biomed Transl Res 2016;17(4):121-125. https://doi.org/10.12729/jbtr.2016.17.4.121 HTML PDF PubReader Last 3 months views: 390	Review A comprehensive review of hypertrophic cardiomyopathy and arterial thromboembolism in cats Donghyun Han, Dong-In Jung J Biomed Transl Res 2019;20(4):82-90. https://doi.org/10.12729/jbtr.2019.20.4.082 HTML PDF PubReader Last 3 months views: 331