Journal of Biomedical and Translational Research

About Journal of Biomedical and Translational Research

Journal of Biomedical and Translational Research is the official journal of Research Institute of Veterinary Medicine, Chungbuk National University. Abbreviated title is 'J. Biomed. Transl. Res.'. It was launched in 2000. It contains reviews, original articles, short communications, and case reports, etc, which generally contain overall review on current research issues, results of novel experiment or investigation, rapid publication for research results, examination of clinical cases, and unique experimental procedures or techniques, respectively. It is published only online quarterly in March 31, June 30, September 30 and December 31 each year. Supplement numbers are times published. All of the manuscripts are peer-reviewed.
Original Article

Mar 31, 2020

Prevention or treatment of enzyme treated royal jelly on monosodium-iodoacetate-induced osteoarthritis

Sun Hwa Hong, Sung Woo Hwang, Yeon Kyung Son, Na Young Lee, Okjin Kim

J Biomed Transl Res 2020;21(1):1-10.
https://doi.org/10.12729/jbtr.2020.21.1.1

Royal jelly (RJ) is a gelatinous substance that bees produce to feed bees and queen bees. It’s frequently sold as a dietary supplement to treat a variety of physical ailments and chronic diseases. While it has long been used in traditional medicine, its applications in Western medicine remain controversial. The inhibitory effect of royal jelly on osteoarthritis was investigated in primary cultured rat cartilage cells and monosodium-iodoacetate (MIA)-induced arthritis rat model 10-hydroxy-2-decenoic acid (10-HAD) is the main fatty acid present...
Original Article

Mar 31, 2020

Detection of acetaminophen-induced liver damage by fluorescence bioimaging, serum biochemistry and histopathological examination

Jin Seok Kang

J Biomed Transl Res 2020;21(1):11-16.
https://doi.org/10.12729/jbtr.2020.21.1.11

The purpose of this study was to examine the characteristics of acetaminophen (APAP)-induced liver damage, using fluorescence bioimaging, serum biochemistry, and histopathology. At six weeks of age, eighteen mice were divided into three groups as group 1 (G1) as control, group 2 (G2) as fluorescence probe control and group 3 (G3) as APAP-treated. G3 mice were orally treated with APAP (800 mg/kg b.w.), while G1 and G2 mice were treated with 0.9% saline. Twenty-two hours after APAP treatment, G2 and G3 mice were intravenously treated with Annexin...
Original Article

Mar 31, 2020

Lysyl oxidase-variant 2 functions as an amine oxidase toward histone H2A

Chunying Li, Anjali Sharma-Bhandari, Youngho Kim

J Biomed Transl Res 2020;21(1):17-23.
https://doi.org/10.12729/jbtr.2020.21.1.17

Lysyl oxidase-variant 2 (LOX-v2) is a novel variant of lysyl oxidase (LOX) that functions as an amine oxidase for the formation of lysine-mediated crosslinks found in collagen and elastin fibrils. In addition to the amine oxidase activity in the extracellular matrix, several novel functions, such as tumor suppression, tumor progression, chemotaxis, cellular senescence, and modification of histones, have been assigned to LOX. In recent years, it has been reported that LOX is also present in nuclear locations, suggesting a novel functional role o...
Original Article

Mar 31, 2020

Quantitative changes innatural antibodies stimulated from a D-galactose-induced aging mouse model

Ji-Hun Park, Seon-Bu Yang, Tae-Saeng Choi

J Biomed Transl Res 2020;21(1):24-29.
https://doi.org/10.12729/jbtr.2020.21.1.24

In previous studies, we found the production of antibodies against cross-reactive bovine serum albumin (BSA) in D-galactose (D-gal) induced aging mouse models. We performed immunoblot analysis with mouse tissue lysates to investigate the changes in the overall autoantibody production in this animal model. And we were able to see the possibility of altering the activity of mouse natural antibodies in this process. In this study, we examined changes in existing natural antibodies in a D-gal-induced aging mouse model. Serum samples were collected ...
Original Article

Mar 31, 2020

A 13-week repeated dose oral toxicity study on a water extract of Artemisia annua in Sprague-Dawley rat

Su-Jin Park, Seong-Hyun Ho, Seon-Hee Kim, Chanyoung Park, Eun-Young Cho, Ji-Ran You

J Biomed Transl Res 2020;21(1):30-37.
https://doi.org/10.12729/jbtr.2020.21.1.30

Artemisia annua (AA) is a well-known as a source of antimalarial drug (artemisinin), which also has been traditionally used as an antipyretic and hemostatic agent in Korea and China. In preclinical effective study, a water extract of Artemisia annua (WEAA) ameliorated weight gain and hepatic lipid accumulation in high-fat diet-fed mice. The plasma levels of triglyceride, AST, and ALT were reduced in the WEAA-treated group. Based on these results, the safety of WEAA as a functional ingredient for liver health wa...

CURRENT ISSUE
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CURRENT ISSUE: Mar 2020, Vol. 21 , No. 1

Original Article Prevention or treatment of enzyme treated royal jelly on monosodium-iodoacetate-induced osteoarthritis Sun Hwa Hong, Sung Woo Hwang, Yeon Kyung Son, Na Young Lee, Okjin Kim J Biomed Transl Res 2020;21(1):1-10. https://doi.org/10.12729/jbtr.2020.21.1.1 HTML PDF PubReader	Original Article Detection of acetaminophen-induced liver damage by fluorescence bioimaging, serum biochemistry and histopathological examination Jin Seok Kang J Biomed Transl Res 2020;21(1):11-16. https://doi.org/10.12729/jbtr.2020.21.1.11 HTML PDF PubReader
Original Article Lysyl oxidase-variant 2 functions as an amine oxidase toward histone H2A Chunying Li, Anjali Sharma-Bhandari, Youngho Kim J Biomed Transl Res 2020;21(1):17-23. https://doi.org/10.12729/jbtr.2020.21.1.17 HTML PDF PubReader	Original Article Quantitative changes innatural antibodies stimulated from a D-galactose-induced aging mouse model Ji-Hun Park, Seon-Bu Yang, Tae-Saeng Choi J Biomed Transl Res 2020;21(1):24-29. https://doi.org/10.12729/jbtr.2020.21.1.24 HTML PDF PubReader
Original Article A 13-week repeated dose oral toxicity study on a water extract of Artemisia annua in Sprague-Dawley rat Su-Jin Park, Seong-Hyun Ho, Seon-Hee Kim, Chanyoung Park, Eun-Young Cho, Ji-Ran You J Biomed Transl Res 2020;21(1):30-37. https://doi.org/10.12729/jbtr.2020.21.1.30 HTML PDF PubReader

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Review Selectins: functional importance as cell adhesion molecule in immune system Yunjeong Noh, Donghyun Cho, Haesu Ko, Dajeong Lim, Han-Ha Chai J Biomed Transl Res 2019;20(4):75-81. https://doi.org/10.12729/jbtr.2019.20.4.075 HTML PDF PubReader Last 3 months views: 208	Original Article Development and validation of LC-MS/MS for bioanalysis of hydroxychloroquine in human whole blood Jung Youl Park, Hyun Ho Song, Young Ee Kwon, Seo Jin Kim, Sukil Jang, Seong Soo Joo J Biomed Transl Res 2018;19(4):130-139. https://doi.org/10.12729/jbtr.2018.19.4.130 HTML PDF PubReader Last 3 months views: 180
Original Article Lysyl oxidase-variant 2 functions as an amine oxidase toward histone H2A Chunying Li, Anjali Sharma-Bhandari, Youngho Kim J Biomed Transl Res 2020;21(1):17-23. https://doi.org/10.12729/jbtr.2020.21.1.17 HTML PDF PubReader Last 3 months views: 171	Original Article Effect of dyslipidemia on vascular smooth muscle cell proliferation in a porcine coronary restenosis model Kang Jin Jeong, Jun Kyu Park, In Ho Bae, Dae Sung Park, Jae Won Shim, Jae Un Kim, Nan Yeol Kim, Sun-Uk Kim, Kyung Seob Lim, Sung Soo Kim, Hyun Kuk Kim, You Jung An, Philyong Kang, Hwal-Yong Lee, Hee Chang Son, Sung Hyun Park, Won Seok Choi, Bon Sang Koo, Chang-Yeop Jeon, Seug Ho Baek, Myung Ho Jeong J Biomed Transl Res 2019;20(4):91-98. https://doi.org/10.12729/jbtr.2019.20.4.091 HTML PDF PubReader Last 3 months views: 170
Original Article A 13-week repeated dose oral toxicity study on a water extract of Artemisia annua in Sprague-Dawley rat Su-Jin Park, Seong-Hyun Ho, Seon-Hee Kim, Chanyoung Park, Eun-Young Cho, Ji-Ran You J Biomed Transl Res 2020;21(1):30-37. https://doi.org/10.12729/jbtr.2020.21.1.30 HTML PDF PubReader Last 3 months views: 156	Original Article Uncertainty of somatosensory evoked potentials during neurosurgical procedure Hoon Kang, Donggeun Lee, Jeongmoon Won J Biomed Transl Res 2019;20(4):105-109. https://doi.org/10.12729/jbtr.2019.20.4.105 HTML PDF PubReader Last 3 months views: 150
Original Article Long term effects after telmisartan administration for cardiovascular-renal axis disorder in cats Donghyun Han, Dong-In Jung J Biomed Transl Res 2019;20(4):99-104. https://doi.org/10.12729/jbtr.2019.20.4.099 HTML PDF PubReader Last 3 months views: 144	Original Article Detection of acetaminophen-induced liver damage by fluorescence bioimaging, serum biochemistry and histopathological examination Jin Seok Kang J Biomed Transl Res 2020;21(1):11-16. https://doi.org/10.12729/jbtr.2020.21.1.11 HTML PDF PubReader Last 3 months views: 138