Journal of Biomedical and Translational Research

About Journal of Biomedical and Translational Research

Journal of Biomedical and Translational Research is the official journal of Research Institute of Veterinary Medicine, Chungbuk National University. Abbreviated title is 'J. Biomed. Transl. Res.'. It was launched in 2000. It contains reviews, original articles, short communications, and case reports, etc, which generally contain overall review on current research issues, results of novel experiment or investigation, rapid publication for research results, examination of clinical cases, and unique experimental procedures or techniques, respectively. It is published only online quarterly in March 31, June 30, September 30 and December 31 each year. Supplement numbers are times published. All of the manuscripts are peer-reviewed.
Review Article

Nov 30, -0001

Targeted protein degradation: therapeutic potential and challenges of PROTACs and molecular glues

Sun Kim, Eui-Bae Jeung

J Biomed Transl Res 2025;26(2):21-34.
https://doi.org/10.12729/jbtr.2025.26.2.21

Targeted protein degradation (TPD) is an emerging therapeutic strategy that leverages the natural protein degradation systems of cells to eliminate disease-associated proteins selectively. Unlike traditional small molecule inhibitors, which merely suppress protein activity, TPD degrades target proteins directly, offering a novel approach to addressing undruggable proteins. The two most extensively studied TPD technologies, proteolysis-targeting chimeras (PROTACs) and molecular glues (MGs), utilize the ubiquitin–proteasome system to induce TPD...
Original Article

Nov 30, -0001

HGF from adipose-derived stem cells protects fibroblasts from apoptosis via c-Met–PI3K/AKT signaling

Dongho Kang, Eunhee Yeon, Taejo Kang, Hyekyung Song, Jiyoung Kim

J Biomed Transl Res 2025;26(2):35-46.
https://doi.org/10.12729/jbtr.2025.26.2.35

Human dermal fibroblasts (HDFs) play a critical role in maintaining skin integrity and promoting tissue repair, but are highly susceptible to apoptosis under stress conditions such as nutrient deprivation. Adipose-derived stem cells (ADSCs) have emerged as a promising therapeutic option due to their regenerative potential and ability to secrete bioactive factors. In this study, we investigated the effect of ADSC-derived paracrine signaling on apoptosis in HDFs and explored the underlying molecular mechanisms. Using a Transwell co-culture system...
Original Article

Nov 30, -0001

Effect of ethyl pyruvate on the artificial insemination liquid of boar spermatozoa

Malavi Arachchi Gamage Nayodya Dananjanee Malavi A Gamage, Wijesooriya Mudhiyanselage Nadeema Dissanayake, Young-Joo Yi

J Biomed Transl Res 2025;26(2):47-58.
https://doi.org/10.12729/jbtr.2025.26.2.47

The success of artificial insemination (AI) in the swine industry relies on conserving the quality of boar sperm during liquid storage, as boar spermatozoa are prone to oxidative stress due to the high polyunsaturated fatty acid content and lack of antioxidant defenses. Sperm motility, viability, acrosome integrity, and DNA stability are all affected by the increases in reactive oxygen species (ROS) during storage, which lowers fertility. Ethyl pyruvate (EP), a stable derivative of pyruvate, has good antioxidant properties and has been shown to...

CURRENT ISSUE: Jun 2025, Vol. 26 , No. 2

Review Article Targeted protein degradation: therapeutic potential and challenges of PROTACs and molecular glues Sun Kim, Eui-Bae Jeung J Biomed Transl Res 2025;26(2):21-34. https://doi.org/10.12729/jbtr.2025.26.2.21 HTML PDF PubReader	Original Article HGF from adipose-derived stem cells protects fibroblasts from apoptosis via c-Met–PI3K/AKT signaling Dongho Kang, Eunhee Yeon, Taejo Kang, Hyekyung Song, Jiyoung Kim J Biomed Transl Res 2025;26(2):35-46. https://doi.org/10.12729/jbtr.2025.26.2.35 HTML PDF PubReader
Original Article Effect of ethyl pyruvate on the artificial insemination liquid of boar spermatozoa Malavi Arachchi Gamage Nayodya Dananjanee Malavi A Gamage, Wijesooriya Mudhiyanselage Nadeema Dissanayake, Young-Joo Yi J Biomed Transl Res 2025;26(2):47-58. https://doi.org/10.12729/jbtr.2025.26.2.47 HTML PDF PubReader

MOST READ ARTICLE

Case Report Clindamycin-doxycycline-metronidazole combination therapy in a refractory canine babesiosis case Hyung-Mo An, Joong-Hyun Song, Su-Jin An, DoHyeon Yu, Donghyun Han, Young Joo Kim, Dong-In Jung J Biomed Transl Res 2019;20(3):71-74. https://doi.org/10.12729/jbtr.2019.20.3.071 HTML PDF PubReader Last 3 months views: 2787	Original Article Echocardiographic evaluation of heart failure in dogs with myxomatous mitral valve disease: a retrospective study Donghyun Han, Dong-Guk Lee, Dong-In Jung J Biomed Transl Res 2018;19(4):79-85. https://doi.org/10.12729/jbtr.2018.19.4.079 HTML PDF PubReader Last 3 months views: 2476
Review A comprehensive review of hypertrophic cardiomyopathy and arterial thromboembolism in cats Donghyun Han, Dong-In Jung J Biomed Transl Res 2019;20(4):82-90. https://doi.org/10.12729/jbtr.2019.20.4.082 HTML PDF PubReader Last 3 months views: 2032	Original Article Retrospective study of 23 dogs with meningoencephalomyelitis of unknown etiology Jun-Hee Kim, Mhan-Pyo Yang, Hakhyun Kim, Jeeyun Kim, Sijin Cha, Dohee Lee, Yeon Chae, Taesik Yun, Yoonhoi Koo, Byeong-Teck Kang J Biomed Transl Res 2022;23(4):203-214. https://doi.org/10.12729/jbtr.2022.23.4.203 HTML PDF PubReader Last 3 months views: 1747
ARTICLE Probiotic dietary supplementation in a dog with chronic kidney disease Sookrang Jo, Minhee Kang, Kyoim Lee, Changmin Lee, Seunggon Kim, Sungjae Park, Taewoo Kim, Heemyung Park J Biomed Res 2014;15(1):40-43. https://doi.org/10.12729/jbr.2014.15.1.040 HTML PDF PubReader Last 3 months views: 1479	Case report Effective treatment of eosinophilic granuloma in a cat using tacrolimus with prednisolone Min-young Moon, Guk-Hyun Suh, Yong-Jin Kwon, Ha-Jung Kim J Biomed Transl Res 2017;18(3):118-120. https://doi.org/10.12729/jbtr.2017.18.3.118 HTML PDF PubReader Last 3 months views: 1439
ARTICLE Poria cocos ethanol extract and its active constituent, pachymic acid, modulate sleep architectures via activation of GABA_A-ergic transmission in rats funcVikash Kumar Shah, Sam-Shik Na, Myong-Soo Chong, Jae-Hoon Woo, Yeong-Ok Kwon, Mi Kyeong Lee, Ki-Wan Oh J Biomed Res 2015;16(3):84-92. https://doi.org/10.12729/jbr.2015.16.3.084 HTML PDF PubReader Last 3 months views: 1427	Original Article Adjuvant treatment with a L-alanyl-L-glutamine supplementation in dogs with parvoviral enteritis Sung-Soo Kim, Dohee Lee, Yeon Chae, Yoonhoi Koo, Taesik Yun, Byeong-Teck Kang, Hakhyun Kim, Mhan-Pyo Yang J Biomed Transl Res 2023;24(2):11-21. https://doi.org/10.12729/jbtr.2023.24.2.11 HTML PDF PubReader Last 3 months views: 1422

MOST CITED ARTICLE

Original Article Classification of stomach cancer gene expression data using CNN algorithm of deep learning Ho Sun Shon, YearnGui Yi, Kyoung Ok Kim, Eun-Jong Cha, Kyung-Ah Kim J Biomed Transl Res 2019;20(1):15-20. https://doi.org/10.12729/jbtr.2019.20.1.015 HTML PDF PubReader Cited by 15	ARTICLE Poria cocos ethanol extract and its active constituent, pachymic acid, modulate sleep architectures via activation of GABA_A-ergic transmission in rats funcVikash Kumar Shah, Sam-Shik Na, Myong-Soo Chong, Jae-Hoon Woo, Yeong-Ok Kwon, Mi Kyeong Lee, Ki-Wan Oh J Biomed Res 2015;16(3):84-92. https://doi.org/10.12729/jbr.2015.16.3.084 HTML PDF PubReader Cited by 10
Original Article Melia azedarach extract exhibits a broad spectrum of antiviral effect in vitro and in vivo N. A. Nadeeka Nethmini, Myun Soo Kim, Kiramage Chathuranga, Jin Yeul Ma, Hongik Kim, Jong-Soo Lee J Biomed Transl Res 2020;21(3):125-136. https://doi.org/10.12729/jbtr.2020.21.3.125 HTML PDF PubReader Cited by 8	Review Article Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms Pritam Bhagwan Bhosale, Sang Eun Ha, Preethi Vetrivel, Hun Hwan Kim, Jin-A Kim, Kwang-Il Park, Seong Min Kim, Gon Sup Kim J Biomed Transl Res 2020;21(2):50-58. https://doi.org/10.12729/jbtr.2020.21.2.050 HTML PDF PubReader Cited by 7
ARTICLE Anti-toxoplasmosis effect of Dictamnus dasycarpus extract against Toxoplasma Gondii Sunhwa Hong, Hyun-A Lee, Yun-seong Lee, Yung-Ho Chung, Okjin Kim J Biomed Res 2014;15(1):7-11. https://doi.org/10.12729/jbr.2014.15.1.007 HTML PDF PubReader Cited by 6	ARTICLE Scanning electron microscopic observation of lingual papillae in a Bengal tiger (Panthera tigris tigris) Munki Kim, Chong-Sup Kim, Gon-Sup Kim, Chung-Kil Won J Biomed Res 2014;15(3):135-140. https://doi.org/10.12729/jbr.2014.15.3.135 HTML PDF PubReader Cited by 6
ARTICLE Protective effect of halophyte Salsola komarovi Iljin against gastric ulcer Induced by alcohol treatment in rats Sunhwa Hong, Hyun-A Lee, Yun-seong Lee, Dong-Woo Kim, Gi-Wook Oh, Jiwan Woo, Yakdol Cho, Jae-Hyeok Jeong, Okjin Kim J Biomed Res 2014;15(4):170-175. https://doi.org/10.12729/jbr.2014.15.4.170 HTML PDF PubReader Cited by 5	ARTICLE Effect of β-glucan from Aureobasidium on dermal wound healing in diabetic C57BL/KsJ-db/db mouse model Sungho Yun, Sae-Kwang Ku, Young-Sam Kwon J Biomed Res 2015;16(4):140-145. https://doi.org/10.12729/jbr.2015.16.4.140 HTML PDF PubReader Cited by 5