Journal of Biomedical and Translational Research

About Journal of Biomedical and Translational Research

Journal of Biomedical and Translational Research is the official journal of Research Institute of Veterinary Medicine, Chungbuk National University. Abbreviated title is 'J. Biomed. Transl. Res.'. It was launched in 2000. It contains reviews, original articles, short communications, and case reports, etc, which generally contain overall review on current research issues, results of novel experiment or investigation, rapid publication for research results, examination of clinical cases, and unique experimental procedures or techniques, respectively. It is published only online quarterly in March 31, June 30, September 30 and December 31 each year. Supplement numbers are times published. All of the manuscripts are peer-reviewed.
Original Article

Nov 30, -0001

The study of the gene expression profiles in the blood of 1-week-old broilers with dietary nutrient modulation

Hyunji Choi, Wonchoul Park, Dajeong Lim, Eui-Chul Hong, Han-Ha Chai
Hyunji Choi, Wonchoul Park, Dajeong Lim, Eui-Chul Hong, Han-Ha Chai

J Biomed Transl Res 2025;26(4):85-96.
https://doi.org/10.12729/jbtr.2025.26.4.85
Original Article

Nov 30, -0001

Diagnosis analysis of apoptotic bodies in rat liver using You Only Look Once (YOLO)v8 object detection algorithm

Gyubaek Kim, Beomseok Han, Da Hui Jeong, Soo Young Cheon

J Biomed Transl Res 2025;26(4):97-106.
https://doi.org/10.12729/jbtr.2025.26.4.97

With advancements in high-resolution scanners and high-performance computers, the use of whole slide imaging (WSI) in digital pathology has increased. WSI scans glass slides and stores them in digital format, making them immune to damage or discoloration, and enabling remote pathology review and peer review. Additionally, with the development of artificial intelligence, research using deep learning models in pathology has become more widespread. In this study, the You Only Look Once (YOLO)v8 model was used to train artificial intelligence to de...
Original Article

Nov 30, -0001

Biocompatibility evaluation of titanium nitride coating for canine patellar groove implant

Yangwon Chae, Euisin Yang, Taehwan Kim, Hyunmin Jo, Dong-Hyun Kim, Byeonghak Kim, Kyung Mi Shim, Se Eun Kim, Seong Soo Kang

J Biomed Transl Res 2025;26(4):107-122.
https://doi.org/10.12729/jbtr.2025.26.4.107

Medial patellar luxation is a common orthopedic disorder in dogs, and advanced cases with severe skeletal deformities or femoropatellar osteoarthritis are often unresponsive to conventional techniques. Patellar groove replacement (PGR) has been proposed as an alternative surgical option; however, systematic comparisons of coating technologies for veterinary PGR implants remain limited. This study aimed to evaluate the physicochemical properties, biological compatibility, and functional performance of a newly developed titanium nitride (TiN)–c...
Original Article

Nov 30, -0001

Glycyrrhizic acid improves fertilization and embryonic development of porcine oocytes fertilized in vitro: focus on HMGB proteins in embryo development

Malavi Arachchi Gamage Nayodya Dananjanee Malavi A Gamage, Wijesooriya Mudhiyanselage Nadeema Dissanayake, Sang-Myeong Lee, Young-Joo Yi

J Biomed Transl Res 2025;26(4):123-134.
https://doi.org/10.12729/jbtr.2025.26.4.123

High-mobility group box-1 (HMGB1) is a conserved nuclear protein that stabilizes the nucleosome and regulates gene transcription. Recent studies have reported that glycyrrhizic acid (GA), a HMGB1 inhibitor, blocks extracellular HMGB1 cytokine activity and has a protective effect in various diseases. This study was performed to investigate the effect of GA on in vitro fertilization (IVF) and embryo culture of pig oocytes. HMGB1 was detected by immunofluorescence in the boar sperm post-acrosomal sheath and sperm tail mid-piece, a...
Original Article

Nov 30, -0001

In vitro application for respiratory toxicity by occupational asthma-related chemicals

Eun-sang Cho

J Biomed Transl Res 2025;26(4):135-144.
https://doi.org/10.12729/jbtr.2025.26.4.135

Occupational respiratory diseases induced by industrial chemicals are well documented. Among these diseases, asthma induced by low-molecular-weight agents such as isocyanates and acid anhydrides commonly used in manufacturing is characterized by dyspnea, chest tightness, and wheezing. We evaluated the effect of low-molecular-weight agents epidemiologically well-established as associated with occupational asthma on normal or pathological states of the human airway epithelium using validated 3D-airway epithelial cell models. Treatment of MucilAir...
Original Article

Nov 30, -0001

Modulation of adipose tissue function by Philadelphus schrenkii extract as a potential anti-obesity agent

Merc Emil Matienzo, Min-Jung Park, Keon Kim, Chang-Min Lee, Hyung-Jun Kwon, In-Chul Lee, Da-Hye Yi, Ji-Hye Ha, Ba-Wool Lee, Dong-il Kim

J Biomed Transl Res 2025;26(4):145-158.
https://doi.org/10.12729/jbtr.2025.26.4.145

Plant-derived natural products, recognized for their bioactive properties and minimal side effects, have been widely explored for their potential in obesity management. Identifying plant-based agents that can modulate adipocyte function with low cytotoxicity is essential for developing safe and effective anti-obesity interventions. In this study, Philadelphus schrenkii (Korean mock orange) was identified as a promising candidate following an initial screening for agents that exhibit minimal cytotoxicity and reduced adipocyte di...
Original Article

Nov 30, -0001

Development of translational murine soft tissue defect model for wound healing research

Yo Han Min, Jinyeong Lim, Sol Lee, Seong Soo Kang, Kyung Mi Shim

J Biomed Transl Res 2025;26(4):159-171.
https://doi.org/10.12729/jbtr.2025.26.4.159

Extensive soft tissue defects involving loss of skin, fat, and muscle often result from trauma or tumor resection. Current treatments, including autografts and flaps, are limited by donor-site morbidity and scarce tissue availability. Animal models, particularly in rodents, are essential for research but are limited by their primary healing mechanism—contraction via the panniculus carnosus—which does not accurately reflect human healing. Furthermore, standardized models for complex skin–muscle defects are lacking. Therefore, this study ai...

CURRENT ISSUE: Dec 2025, Vol. 26 , No. 4

Original Article The study of the gene expression profiles in the blood of 1-week-old broilers with dietary nutrient modulation Hyunji Choi, Wonchoul Park, Dajeong Lim, Eui-Chul Hong, Han-Ha Chai J Biomed Transl Res 2025;26(4):85-96. https://doi.org/10.12729/jbtr.2025.26.4.85 HTML PDF PubReader	Original Article Diagnosis analysis of apoptotic bodies in rat liver using You Only Look Once (YOLO)v8 object detection algorithm Gyubaek Kim, Beomseok Han, Da Hui Jeong, Soo Young Cheon J Biomed Transl Res 2025;26(4):97-106. https://doi.org/10.12729/jbtr.2025.26.4.97 HTML PDF PubReader
Original Article Biocompatibility evaluation of titanium nitride coating for canine patellar groove implant Yangwon Chae, Euisin Yang, Taehwan Kim, Hyunmin Jo, Dong-Hyun Kim, Byeonghak Kim, Kyung Mi Shim, Se Eun Kim, Seong Soo Kang J Biomed Transl Res 2025;26(4):107-122. https://doi.org/10.12729/jbtr.2025.26.4.107 HTML PDF PubReader	Original Article Glycyrrhizic acid improves fertilization and embryonic development of porcine oocytes fertilized in vitro: focus on HMGB proteins in embryo development Malavi Arachchi Gamage Nayodya Dananjanee Malavi A Gamage, Wijesooriya Mudhiyanselage Nadeema Dissanayake, Sang-Myeong Lee, Young-Joo Yi J Biomed Transl Res 2025;26(4):123-134. https://doi.org/10.12729/jbtr.2025.26.4.123 HTML PDF PubReader
Original Article In vitro application for respiratory toxicity by occupational asthma-related chemicals Eun-sang Cho J Biomed Transl Res 2025;26(4):135-144. https://doi.org/10.12729/jbtr.2025.26.4.135 HTML PDF PubReader	Original Article Modulation of adipose tissue function by Philadelphus schrenkii extract as a potential anti-obesity agent Merc Emil Matienzo, Min-Jung Park, Keon Kim, Chang-Min Lee, Hyung-Jun Kwon, In-Chul Lee, Da-Hye Yi, Ji-Hye Ha, Ba-Wool Lee, Dong-il Kim J Biomed Transl Res 2025;26(4):145-158. https://doi.org/10.12729/jbtr.2025.26.4.145 HTML PDF PubReader
Original Article Development of translational murine soft tissue defect model for wound healing research Yo Han Min, Jinyeong Lim, Sol Lee, Seong Soo Kang, Kyung Mi Shim J Biomed Transl Res 2025;26(4):159-171. https://doi.org/10.12729/jbtr.2025.26.4.159 HTML PDF PubReader

MOST READ ARTICLE

Case Report Clindamycin-doxycycline-metronidazole combination therapy in a refractory canine babesiosis case Hyung-Mo An, Joong-Hyun Song, Su-Jin An, DoHyeon Yu, Donghyun Han, Young Joo Kim, Dong-In Jung J Biomed Transl Res 2019;20(3):71-74. https://doi.org/10.12729/jbtr.2019.20.3.071 HTML PDF PubReader Last 3 months views: 3980	Review A comprehensive review of hypertrophic cardiomyopathy and arterial thromboembolism in cats Donghyun Han, Dong-In Jung J Biomed Transl Res 2019;20(4):82-90. https://doi.org/10.12729/jbtr.2019.20.4.082 HTML PDF PubReader Last 3 months views: 2942
Original Article Echocardiographic evaluation of heart failure in dogs with myxomatous mitral valve disease: a retrospective study Donghyun Han, Dong-Guk Lee, Dong-In Jung J Biomed Transl Res 2018;19(4):79-85. https://doi.org/10.12729/jbtr.2018.19.4.079 HTML PDF PubReader Last 3 months views: 2764	ARTICLE Probiotic dietary supplementation in a dog with chronic kidney disease Sookrang Jo, Minhee Kang, Kyoim Lee, Changmin Lee, Seunggon Kim, Sungjae Park, Taewoo Kim, Heemyung Park J Biomed Res 2014;15(1):40-43. https://doi.org/10.12729/jbr.2014.15.1.040 HTML PDF PubReader Last 3 months views: 2634
Original Article Adjuvant treatment with a L-alanyl-L-glutamine supplementation in dogs with parvoviral enteritis Sung-Soo Kim, Dohee Lee, Yeon Chae, Yoonhoi Koo, Taesik Yun, Byeong-Teck Kang, Hakhyun Kim, Mhan-Pyo Yang J Biomed Transl Res 2023;24(2):11-21. https://doi.org/10.12729/jbtr.2023.24.2.11 HTML PDF PubReader Last 3 months views: 2394	Original Article Retrospective study of 23 dogs with meningoencephalomyelitis of unknown etiology Jun-Hee Kim, Mhan-Pyo Yang, Hakhyun Kim, Jeeyun Kim, Sijin Cha, Dohee Lee, Yeon Chae, Taesik Yun, Yoonhoi Koo, Byeong-Teck Kang J Biomed Transl Res 2022;23(4):203-214. https://doi.org/10.12729/jbtr.2022.23.4.203 HTML PDF PubReader Last 3 months views: 2236
ARTICLE Poria cocos ethanol extract and its active constituent, pachymic acid, modulate sleep architectures via activation of GABA_A-ergic transmission in rats funcVikash Kumar Shah, Sam-Shik Na, Myong-Soo Chong, Jae-Hoon Woo, Yeong-Ok Kwon, Mi Kyeong Lee, Ki-Wan Oh J Biomed Res 2015;16(3):84-92. https://doi.org/10.12729/jbr.2015.16.3.084 HTML PDF PubReader Last 3 months views: 2006	Review Article Targeted protein degradation: therapeutic potential and challenges of PROTACs and molecular glues Sun Kim, Eui-Bae Jeung J Biomed Transl Res 2025;26(2):21-34. https://doi.org/10.12729/jbtr.2025.26.2.21 HTML PDF PubReader Last 3 months views: 1981

MOST CITED ARTICLE

Original Article Classification of stomach cancer gene expression data using CNN algorithm of deep learning Ho Sun Shon, YearnGui Yi, Kyoung Ok Kim, Eun-Jong Cha, Kyung-Ah Kim J Biomed Transl Res 2019;20(1):15-20. https://doi.org/10.12729/jbtr.2019.20.1.015 HTML PDF PubReader Cited by 17	ARTICLE Poria cocos ethanol extract and its active constituent, pachymic acid, modulate sleep architectures via activation of GABA_A-ergic transmission in rats funcVikash Kumar Shah, Sam-Shik Na, Myong-Soo Chong, Jae-Hoon Woo, Yeong-Ok Kwon, Mi Kyeong Lee, Ki-Wan Oh J Biomed Res 2015;16(3):84-92. https://doi.org/10.12729/jbr.2015.16.3.084 HTML PDF PubReader Cited by 10
Original Article Melia azedarach extract exhibits a broad spectrum of antiviral effect in vitro and in vivo N. A. Nadeeka Nethmini, Myun Soo Kim, Kiramage Chathuranga, Jin Yeul Ma, Hongik Kim, Jong-Soo Lee J Biomed Transl Res 2020;21(3):125-136. https://doi.org/10.12729/jbtr.2020.21.3.125 HTML PDF PubReader Cited by 8	Review Article Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms Pritam Bhagwan Bhosale, Sang Eun Ha, Preethi Vetrivel, Hun Hwan Kim, Jin-A Kim, Kwang-Il Park, Seong Min Kim, Gon Sup Kim J Biomed Transl Res 2020;21(2):50-58. https://doi.org/10.12729/jbtr.2020.21.2.050 HTML PDF PubReader Cited by 7
ARTICLE Anti-toxoplasmosis effect of Dictamnus dasycarpus extract against Toxoplasma Gondii Sunhwa Hong, Hyun-A Lee, Yun-seong Lee, Yung-Ho Chung, Okjin Kim J Biomed Res 2014;15(1):7-11. https://doi.org/10.12729/jbr.2014.15.1.007 HTML PDF PubReader Cited by 6	ARTICLE Scanning electron microscopic observation of lingual papillae in a Bengal tiger (Panthera tigris tigris) Munki Kim, Chong-Sup Kim, Gon-Sup Kim, Chung-Kil Won J Biomed Res 2014;15(3):135-140. https://doi.org/10.12729/jbr.2014.15.3.135 HTML PDF PubReader Cited by 6
ARTICLE Protective effect of halophyte Salsola komarovi Iljin against gastric ulcer Induced by alcohol treatment in rats Sunhwa Hong, Hyun-A Lee, Yun-seong Lee, Dong-Woo Kim, Gi-Wook Oh, Jiwan Woo, Yakdol Cho, Jae-Hyeok Jeong, Okjin Kim J Biomed Res 2014;15(4):170-175. https://doi.org/10.12729/jbr.2014.15.4.170 HTML PDF PubReader Cited by 5	ARTICLE Effect of β-glucan from Aureobasidium on dermal wound healing in diabetic C57BL/KsJ-db/db mouse model Sungho Yun, Sae-Kwang Ku, Young-Sam Kwon J Biomed Res 2015;16(4):140-145. https://doi.org/10.12729/jbr.2015.16.4.140 HTML PDF PubReader Cited by 5