Journal of Biomedical and Translational Research

About Journal of Biomedical and Translational Research

Journal of Biomedical and Translational Research is the official journal of Research Institute of Veterinary Medicine, Chungbuk National University. Abbreviated title is 'J. Biomed. Transl. Res.'. It was launched in 2000. It contains reviews, original articles, short communications, and case reports, etc, which generally contain overall review on current research issues, results of novel experiment or investigation, rapid publication for research results, examination of clinical cases, and unique experimental procedures or techniques, respectively. It is published only online quarterly in March 31, June 30, September 30 and December 31 each year. Supplement numbers are times published. All of the manuscripts are peer-reviewed.
Original Article

Nov 30, -0001

Comparative analysis of bisphenol A effects on HT-29 cell line and mouse intestinal organoids

Eunju Jang, Changhwan Ahn

J Biomed Transl Res 2024;25(3):107-117.
https://doi.org/10.12729/jbtr.2024.25.3.107

Cell culture is a widely used in vitro tool that enhances our understanding of cell biology, disease mechanisms, drug responses, and the development of tissue engineering. However, there are a number of important drawbacks to conventional two-dimensional (2D) cultures, such as the loss of polarity, altered cell shape, and disruption of cell-extracellular matrix connections. Alternatively, organoids are tissue-engineered, cell-based in vitro models derived from stem cells that can self-organize and differentiate...
Original Article

Nov 30, -0001

Subchronic inhalation toxicity study of diethylbenzene in Wistar rats

Eun-Sang Cho, Dae-Sik Rha

J Biomed Transl Res 2024;25(3):119-132.
https://doi.org/10.12729/jbtr.2024.25.3.119

Diethylbenzene (DEB) is a colorless flammable liquid composed of a benzene ring and two ethyl substituents. DEBs mostly exist as a mixture of isomers and are mainly used as intermediates and solvents occupationally. Workers may be exposed to DEB inhalation during their occupational activities including manufacturing or processing of materials; however, limited data are available on the risk assessment of DEB mixtures. In this study, male and female Wistar rats were exposed to vapors of a DEB mixture for 13-weeks (6 hr/day, 5 days/week) at conce...
Original Article

Nov 30, -0001

Effect of Korean Red Ginseng on the stress-derived plasma hormone and lipid levels and oxidative stress in mice

Chun-Sik Bae, Youngchan Lee, Taeho Ahn

J Biomed Transl Res 2024;25(3):133-144.
https://doi.org/10.12729/jbtr.2024.25.3.133

We investigated the stress-induced changes in the lipid and hormonal concentrations in plasma, including cytochrome P450 (CYP)-derived oxidative stress in the liver, and the anti-stress effect of Korean Red Ginseng (KRG) water extract in mice. Stress induction using restraint increased the levels of corticosterone (CORT), glucose, total cholesterol (TC), and low-density lipoprotein-cholesterol (LDL-C) while decreasing in the levels of insulin and high-density lipoprotein-cholesterol (HDL-C), compared with those of unstressed mice. Restraint-str...
Original Article

Nov 30, -0001

Age-dependent change trends of clinicopathological parameters in F344 rats

Mi Ju Lee, Jeong-Hee Han, Minha Kim

J Biomed Transl Res 2024;25(3):145-160.
https://doi.org/10.12729/jbtr.2024.25.3.145

Clinical pathology, including hematology and serum chemistry, is an important indicator of biological changes. Animals for inhalation studies are kept in specific chambers and require historical data for accuracy. Age-related characteristics are essential for interpreting experimental results. This study aimed to provide historical clinical pathology data and analyze age-related trends in these parameters. We collected hematological and biochemical parameters from control groups of male and female F344 rats in the 4-, 13-, 26-, and 52-week repe...
Original Article

Nov 30, -0001

Clinical factors associated with canine subclinical myxomatous mitral valve disease stage progression in South Korea

Isaac Yang, Kyung-Duk Min
Isaac Yang, Kyung-Duk Min

J Biomed Transl Res 2024;25(3):161-167.
https://doi.org/10.12729/jbtr.2024.25.3.161

CURRENT ISSUE: Sep 2024, Vol. 25 , No. 3

Original Article Comparative analysis of bisphenol A effects on HT-29 cell line and mouse intestinal organoids Eunju Jang, Changhwan Ahn J Biomed Transl Res 2024;25(3):107-117. https://doi.org/10.12729/jbtr.2024.25.3.107 HTML PDF PubReader	Original Article Subchronic inhalation toxicity study of diethylbenzene in Wistar rats Eun-Sang Cho, Dae-Sik Rha J Biomed Transl Res 2024;25(3):119-132. https://doi.org/10.12729/jbtr.2024.25.3.119 HTML PDF PubReader
Original Article Effect of Korean Red Ginseng on the stress-derived plasma hormone and lipid levels and oxidative stress in mice Chun-Sik Bae, Youngchan Lee, Taeho Ahn J Biomed Transl Res 2024;25(3):133-144. https://doi.org/10.12729/jbtr.2024.25.3.133 HTML PDF PubReader	Original Article Age-dependent change trends of clinicopathological parameters in F344 rats Mi Ju Lee, Jeong-Hee Han, Minha Kim J Biomed Transl Res 2024;25(3):145-160. https://doi.org/10.12729/jbtr.2024.25.3.145 HTML PDF PubReader
Original Article Clinical factors associated with canine subclinical myxomatous mitral valve disease stage progression in South Korea Isaac Yang, Kyung-Duk Min J Biomed Transl Res 2024;25(3):161-167. https://doi.org/10.12729/jbtr.2024.25.3.161 HTML PDF PubReader

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Review Flavonoids over women’s health: a literature review Jin-A Kim, Eun Hee Kim J Biomed Transl Res 2018;19(2):32-37. https://doi.org/10.12729/jbtr.2018.19.2.032 HTML PDF PubReader Last 3 months views: 2691	Case Report Clindamycin-doxycycline-metronidazole combination therapy in a refractory canine babesiosis case Hyung-Mo An, Joong-Hyun Song, Su-Jin An, DoHyeon Yu, Donghyun Han, Young Joo Kim, Dong-In Jung J Biomed Transl Res 2019;20(3):71-74. https://doi.org/10.12729/jbtr.2019.20.3.071 HTML PDF PubReader Last 3 months views: 1846
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Case Report A case of canine blepharoconjunctivitis associated with atopic dermatitis Yoonji Kim, Hyeon-Jin Kim, Ji-Hee Kim, Ji-Hye Lee, Soomin Kim, Se Eun Kim, Taejung Kim, Ha-Jung Kim J Biomed Transl Res 2021;22(2):100-104. https://doi.org/10.12729/jbtr.2021.22.2.100 HTML PDF PubReader Last 3 months views: 1039	Original Article Retrospective study of 23 dogs with meningoencephalomyelitis of unknown etiology Jun-Hee Kim, Mhan-Pyo Yang, Hakhyun Kim, Jeeyun Kim, Sijin Cha, Dohee Lee, Yeon Chae, Taesik Yun, Yoonhoi Koo, Byeong-Teck Kang J Biomed Transl Res 2022;23(4):203-214. https://doi.org/10.12729/jbtr.2022.23.4.203 HTML PDF PubReader Last 3 months views: 919
Case report Hematometra in a young Poongsan dog with continuous vulvar hemorrhage Hyun-Sik Kim, Ill-Hwa Kim, Hyun-Gu Kang J Biomed Transl Res 2016;17(4):121-125. https://doi.org/10.12729/jbtr.2016.17.4.121 HTML PDF PubReader Last 3 months views: 855	Case report Clinical application of dapsone in two cases of canine sterile nodular panniculitis Sun-Hwa Kim, Sun-Hyung Cho, Ji-Houn Kang, Mhan-Pyo Yang, In-Pil Mo, Byeong-Teck Kang J Biomed Transl Res 2016;17(4):115-120. https://doi.org/10.12729/jbtr.2016.17.4.115 HTML PDF PubReader Last 3 months views: 685

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Original Article Classification of stomach cancer gene expression data using CNN algorithm of deep learning Ho Sun Shon, YearnGui Yi, Kyoung Ok Kim, Eun-Jong Cha, Kyung-Ah Kim J Biomed Transl Res 2019;20(1):15-20. https://doi.org/10.12729/jbtr.2019.20.1.015 HTML PDF PubReader Cited by 12	ARTICLE Poria cocos ethanol extract and its active constituent, pachymic acid, modulate sleep architectures via activation of GABA_A-ergic transmission in rats funcVikash Kumar Shah, Sam-Shik Na, Myong-Soo Chong, Jae-Hoon Woo, Yeong-Ok Kwon, Mi Kyeong Lee, Ki-Wan Oh J Biomed Res 2015;16(3):84-92. https://doi.org/10.12729/jbr.2015.16.3.084 HTML PDF PubReader Cited by 10
Original Article Melia azedarach extract exhibits a broad spectrum of antiviral effect in vitro and in vivo N. A. Nadeeka Nethmini, Myun Soo Kim, Kiramage Chathuranga, Jin Yeul Ma, Hongik Kim, Jong-Soo Lee J Biomed Transl Res 2020;21(3):125-136. https://doi.org/10.12729/jbtr.2020.21.3.125 HTML PDF PubReader Cited by 7	ARTICLE Anti-toxoplasmosis effect of Dictamnus dasycarpus extract against Toxoplasma Gondii Sunhwa Hong, Hyun-A Lee, Yun-seong Lee, Yung-Ho Chung, Okjin Kim J Biomed Res 2014;15(1):7-11. https://doi.org/10.12729/jbr.2014.15.1.007 HTML PDF PubReader Cited by 6
ARTICLE Scanning electron microscopic observation of lingual papillae in a Bengal tiger (Panthera tigris tigris) Munki Kim, Chong-Sup Kim, Gon-Sup Kim, Chung-Kil Won J Biomed Res 2014;15(3):135-140. https://doi.org/10.12729/jbr.2014.15.3.135 HTML PDF PubReader Cited by 6	Review Article Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms Pritam Bhagwan Bhosale, Sang Eun Ha, Preethi Vetrivel, Hun Hwan Kim, Jin-A Kim, Kwang-Il Park, Seong Min Kim, Gon Sup Kim J Biomed Transl Res 2020;21(2):50-58. https://doi.org/10.12729/jbtr.2020.21.2.050 HTML PDF PubReader Cited by 6
ARTICLE Protective effect of halophyte Salsola komarovi Iljin against gastric ulcer Induced by alcohol treatment in rats Sunhwa Hong, Hyun-A Lee, Yun-seong Lee, Dong-Woo Kim, Gi-Wook Oh, Jiwan Woo, Yakdol Cho, Jae-Hyeok Jeong, Okjin Kim J Biomed Res 2014;15(4):170-175. https://doi.org/10.12729/jbr.2014.15.4.170 HTML PDF PubReader Cited by 5	ARTICLE Effect of β-glucan from Aureobasidium on dermal wound healing in diabetic C57BL/KsJ-db/db mouse model Sungho Yun, Sae-Kwang Ku, Young-Sam Kwon J Biomed Res 2015;16(4):140-145. https://doi.org/10.12729/jbr.2015.16.4.140 HTML PDF PubReader Cited by 5