Table 3. ROS/RNS levels induced by MDI, TDI and TMA in the in vitro cell models

Models		MucilAir™				SmallAir™				SmallAir-Asthma™
Groups	Con	Low	Middle	High	Con	Low	Middle	High	Con	Low	Middle	High
	(uM)				(uM)				(uM)
MDI	0.53 ± 0.04	0.53 ± 0.04	0.55 ± 0.05	0.54 ± 0.04	0.53 ± 0.06	0.53 ± 0.05	0.52 ± 0.06	50.54 ± 0.05	0.51 ± 0.05	0.52 ± 0.05	0.50 ± 0.04	0.53 ± 0.05
TDI		0.55 ± 0.06	0.57 ± 0.06	0.58 ± 0.06		0.57 ± 0.05	0.63 ± 0.06	0.61 ± 0.06		0.51 ± 0.05	0.51 ± 0.05	0.60 ± 0.02
TMA		0.55 ± 0.05	0.54 ± 0.05	0.55 ± 0.05		0.52 ± 0.05	0.52 ± 0.05	0.53 ± 0.05		0.55 ± 0.05	0.52 ± 0.04	0.52 ± 0.05

Data are expressed as the mean ± S.D.
ROS, reactive oxygen species; RNS, reactive nitrogen species; MDI, methylene diphenyl diisocyanate; TDI, toluene diisocyanate; TMA, trimellitic anhydride; Con, control.