Table 3. Current clinical-stage MGs

Complound Target protein Indication Reference
CC-92480 IKZF1/3 MM [75]
CC-90009 GSPT1 AML, MDS [76]
CC-220 IKZF1/3 Relapsed/refractory MM, NHL, systemic lupus erythematosus. [77]
E7820 RBM39 Relapsed or refractory AML, MDS or chronic myelomonocytic leukemia [78]
CFT 7455 IKZF1/3 MM, NHL [79]
NVP-DKY709 IKZF2 Cancer immunotherapy [80]
MGs, molecular glues; IKZF, ikaros; MM, multiple myeloma; GSPT1, G1 to S phase transition 1; AML, acute myeloid leukemia; MDS, myeloid dysplasia syndrome; NHL, non-Hodgkin’s lymphoma.