Table 1. Key differences between PROTACs and MGs

	PROTACs	MGs
Mechanism	Induces protein degradation via E3 ligase recruitment	Enhances PPI
Structure	Bifunctional molecule with a linker	Small molecule
Discovery	Enables rational design	Mostly serendipitous
Target	Broad (E3 ligase-dependent) and predictable	Limited (PPI-dependent) and undetermined
Cell permeability	Lower (large size)	Higher (small size)
Optimization	Challenging (PK issues)	Easier (small-molecule properties)

PROTACs, proteolysis-targeting chimeras; MGs, molecular glues; PPI, protein-protein interactions; PK, pharmacokinetic.