Table 9. Serum chemistry data for F344 rats exposed to fresh air in whole body chamber

Experimental week	4	13	26	52
No. of animals	25	60	50	25
Females
ALT (IU/L)	40.3 ± 11.7	41.8 ± 9.5	85.2 ± 40.5**	73.1 ± 22.7**
AST (IU/L)	81.5 ± 10.5	96.2 ± 15.3*	136.8 ± 38.7	153.1 ± 60.2**
ALP (IU/L)	537 ± 53	295 ± 44**	279 ± 37**	203 ± 33**
TBIL (mg/dL)	0.16 ± 0.03	0.15 ± 0.02	0.14 ± 0.03*	0.14 ± 0.04
TP (g/dL)	5.7 ± 0.5	6.3 ± 0.4**	7.0 ± 0.4**	7.5 ± 0.4**
ALB (g/dL)	4.0 ± 0.3	4.2 ± 0.2**	4.5 ± 0.2**	4.8 ± 0.2**
A/G ratio	2.25 ± 0.16	2.00 ± 0.12**	1.78 ± 0.11**	1.77 ± 0.08**
TG (mg/dL)	24.5 ± 20.0	21.8 ± 8.6	33.7 ± 16.0*	49.4 ± 15.8**
TCHO (mg/dL)	74.8 ± 11.1	89.6 ± 11.0**	99.2 ± 12.8**	140.2 ± 12.7**
GLU (mg/dL)	127 ± 14	115 ± 18	120 ± 12	161 ± 10**
BUN (mg/dL)	20.2 ± 3.7	19.1 ± 2.5	20.6 ± 2.2	21.9 ± 2.3
CREA (mg/dL)	0.40 ± 0.03	0.42 ± 0.04	0.43 ± 0.04**	0.47 ± 0.04**
Na (mmol/L)	137.8 ± 10.2	136.4 ± 10.9	148.9 ± 1.8**	142.5 ± 1.1
Cl (mmol/L)	100.4 ± 8.4	99.3 ± 8.0	107.8 ± 2.1**	104.1 ± 1.4
K (mmol/L)	4.14 ± 0.43	4.00 ± 0.41	4.64 ± 0.71**	4.00 ± 0.36
Ca (mg/dL)	9.6 ± 0.8	9.7 ± 0.9	10.8 ± 1.1**	10.3 ± 0.3**
IP (mg/dL)	6.7 ± 1.0	4.9 ± 0.8**	5.8 ± 1.2*	4.1 ± 1.0**

Differences among ages are expressed as p<0.05,
p<0.01 based on the result of Dunnett’s or Dunn’s test.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; TBIL, total bilirubin; TP, total protein; ALB, albumin; A/G, albumin/globulin; TG, triglyceride; TCHO, total cholesterol; GLU, glucose; BUN, blood urea nitrogen; CREA, creatinine; Na, sodium; Cl, chloride; K, potassium; Ca, calcium; IP, inorganic phosphorus.