Table 6. Serum chemistry data for F344 rats exposed to fresh air in whole-body chamber

Experimental week	4	13	26	52
No. of animals	25	60	50	25
Males
ALT (IU/L)	42.6 ± 13.8	46.8 ± 13.6	111.5 ± 45.2**	117.8 ± 38.8**
AST (IU/L)	79.5 ± 11.6	93.2 ± 20.5	162.7 ± 42.2**	167.4 ± 39.4**
ALP (IU/L)	697 ± 39	397 ± 49**	317 ± 32**	323 ± 30**
TBIL (mg/dL)	0.18 ± 0.04	0.17 ± 0.03	0.20 ± 0.03	0.20 ± 0.00
TP (g/dL)	5.6 ± 0.4	6.1 ± 0.5**	6.8 ± 0.3**	6.5 ± 0.2**
ALB (g/dL)	3.9 ± 0.2	4.1 ± 0.3**	4.3 ± 0.2**	4.2 ± 0.1**
A/G ratio	2.24 ± 0.11	2.04 ± 0.13**	1.79 ± 0.08**	1.77 ± 0.06**
TG (mg/dL)	53.9 ± 15.5	96.3 ± 46.6**	100.4 ± 34.4**	135.1 ± 47.6**
TCHO (mg/dL)	62.2 ± 5.7	77.3 ± 12.2**	76.2 ± 7.0**	127.3 ± 15.0**
GLU (mg/dL)	161 ± 18	145 ± 29*	131 ± 10**	179 ± 26
BUN (mg/dL)	18.6 ± 2.6	17.4 ± 2.9	19.9 ± 2.0	18.7 ± 1.6
CREA (mg/dL)	0.41 ± 0.05	0.44 ± 0.05	0.42 ± 0.03	0.45 ± 0.03**
Na (mmol/L)	137.2 ± 9.9	135.6 ± 11.0	143.8 ± 5.2**	143.1 ± 0.7
Cl (mmol/L)	97.3 ± 7.0	95.9 ± 7.9	103.3 ± 3.8**	103.7 ± 0.9**
K (mmol/L)	4.31 ± 0.60	4.19 ± 0.43	4.43 ± 0.28	4.33 ± 0.25
Ca (mg/dL)	9.5 ± 0.8	9.8 ± 1.1	9.9 ± 0.4**	10.0 ± 0.2
IP (mg/dL)	6.6 ± 1.0	5.4 ± 0.8**	6.2 ± 0.5*	4.5 ± 0.8**

Differences among ages are expressed as p<0.05,
p<0.01, based on Dunnett’s or Dunn’s test.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; TBIL, total bilirubin; TP, total protein; ALB, albumin; A/G, albumin/globulin; TG, triglyceride; TCHO, total cholesterol; GLU, glucose; BUN, blood urea nitrogen; CREA, creatinine; Na, sodium; Cl, chloride; K, potassium; Ca, calcium; IP, inorganic phosphorus.