Table 4. Hematology data for F344 rats exposed to fresh air in whole-body chamber

Experimental week	4	13	26	52
No. of animals¹⁾	25	60	50	25
Females
RBC (× 10⁶/µL)	8.54 ± 0.37	8.46 ± 0.22	8.29 ± 0.32^**	8.16 ± 0.25^**
HGB (g/dL)	15.0 ± 0.6	14.6 ± 0.4^**	15.3 ± 0.5	14.8 ± 0.4
HCT (%)	43.2 ± 1.3	42.1 ± 0.9^**	42.6 ± 1.9	43.1 ± 1.1
MCV (fL)	50.6 ± 1.1	49.8 ± 0.6^**	51.4 ± 0.5^**	52.8 ± 1.0^**
MCH (pg)	17.6 ± 0.4	17.3 ± 0.4^**	18.4 ± 0.3^**	18.1 ± 0.4^**
MCHC (g/dL)	34.8 ± 0.9	34.7 ± 0.7	35.8 ± 0.6^**	34.4 ± 0.5
RETA (× 10³/µL)	232.2 ± 158.3	184.7 ± 25.7	171.0 ± 18.9^**	182.4 ± 51.3^**
RET% (%)	2.8 ± 2.3	2.2 ± 0.3	2.1 ± 0.3^*	2.2 ± 0.7
WBC (× 10³/µL)	3.13 ± 0.87	2.84 ± 0.80	2.77 ± 0.73^*	1.42 ± 0.36^**
LYMA (× 10³/µL)	2.37 ± 0.73	1.97 ± 0.61^**	1.76 ± 0.54^*	0.80 ± 0.28^**
NEUA (× 10³/µL)	0.62 ± 0.16	0.73 ± 0.24^**	0.87 ± 0.34	0.51 ± 0.18
EOSA (× 10³/µL)	0.04 ± 0.01	0.05 ± 0.02	0.04 ± 0.02	0.03 ± 0.02
BASA (× 10³/µL)	0.01 ± 0.01	0.00 ± 0.00	0.00 ± 0.00^**	0.00 ± 0.00^**
MONA (× 10³/µL)	0.06 ± 0.03	0.07 ± 0.07	0.07 ± 0.02	0.05 ± 0.02
LYM% (%)	75.5 ± 4.1	69.2 ± 8.7^*	63.1 ± 8.0^**	56.1 ± 14.2^**
NEU% (%)	20.4 ± 4.0	25.8 ± 6.0^**	31.9 ± 8.2^**	36.9 ± 12.6^**
EOS% (%)	1.5 ± 0.4	1.8 ± 0.6	1.5 ± 0.8	2.4 ± 1.9^*
BAS% (%)	0.2 ± 0.1	0.2 ± 0.1^*	0.1 ± 0.1^**	0.1 ± 0.1^**
MON% (%)	1.9 ± 0.6	2.5 ± 3.7	2.5 ± 0.5	3.5 ± 0.8
PLT (× 10³/µL)	808 ± 99	742 ± 51^*	649 ± 85^**	534 ± 169^**
APTT (sec)	17.5 ± 2.1	18.7 ± 2.0	19.3 ± 4.1	21.0 ± 1.8^**
PT (sec)	10.5 ± 0.7	10.4 ± 0.5	10.0 ± 0.7	9.9 ± 0.4^**

Differences among ages are expressed as p<0.05,
p<0.01 based on the result of Dunnett’s or Dunn’s test.
APTT and PT were examined in 21 females in the 52-week study.
RBC, red blood cell; HGB, hemoglobin; HCT, hematocrit; MCV, mean cell volume; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; RETA, reticulocyte count; RET%, reticulocyte percentage; WBC, white blood cell; LYMA, lymphocyte count; NEUA, neutrophil count; EOSA, eosinophil count; BASA, basophil count; MONA, monocyte count; LYM%, lymphocyte percentage; NEU%, neutrophil percentage; EOS%, eosinophil percentage; BAS%, basophil percentage; MON%, monocyte percentage; PLT, platelet; APTT, activated partial thromboplastin time; PT, prothrombin time.