Table 1. Hematology data for F344 rats exposed to fresh air in whole-body chamber

Experimental week	4	13	26	52
No. of animals1)	24	60	50	25
Males
RBC (× 106/µL)	8.78 ± 0.26	9.04 ± 0.20**	9.02 ± 0.36**	8.85 ± 0.38
HGB (g/dL)	14.9 ± 0.5	14.8 ± 0.3	14.9 ± 1.9	15.0 ± 0.6
HCT (%)	43.5 ± 1.1	43.3 ± 0.8	42.8 ± 1.6*	43.9 ± 1.7
MCV (fL)	49.6 ± 0.5	47.9 ± 0.7**	47.4 ± 0.8**	49.7 ± 0.7
MCH (pg)	17.0 ± 0.4	16.4 ± 0.4**	16.9 ± 0.3*	17.0 ± 0.3
MCHC (g/dL)	34.3 ± 0.7	34.2 ± 0.7	35.6 ± 0.7**	34.3 ± 0.4
RETA (× 103/µL)	204.2 ± 27.3	226.1 ± 24.9**	207.2 ± 24.6	214.7 ± 25.5
RET% (%)	2.3 ± 0.3	2.5 ± 0.3*	2.3 ± 0.3	2.4 ± 0.3
WBC (× 10³/µL)	3.97 ± 0.90	4.47 ± 0.86*	4.91 ± 0.88**	3.64 ± 0.65
LYMA (× 103/µL)	2.93 ± 0.77	2.96 ± 0.64	2.67 ± 0.57*	1.88 ± 0.33**
NEUA (× 103/µL)	0.89 ± 0.31	1.29 ± 0.33**	1.99 ± 0.63**	1.56 ± 0.41**
EOSA (× 103/µL)	0.05 ± 0.02	0.08 ± 0.02**	0.07 ± 0.02**	0.08 ± 0.02**
BASA (× 103/µL)	0.01 ± 0.01	0.01 ± 0.01**	0.01 ± 0.00	0.00 ± 0.00
MONA (× 103/µL)	0.07 ± 0.02	0.10 ± 0.03	0.13 ± 0.04**	0.10 ± 0.03
LYM% (%)	73.5 ± 6.7	66.2 ± 5.6*	54.6 ± 8.3**	51.9 ± 5.6**
NEU% (%)	22.8 ± 6.8	28.9 ± 5.3*	40.2 ± 8.8**	42.5 ± 5.7**
EOS% (%)	1.4 ± 0.7	1.8 ± 0.5*	1.5 ± 0.4	2.2 ± 0.5**
BAS% (%)	0.2 ± 0.1	0.2 ± 0.1	0.1 ± 0.1**	0.1 ± 0.1**
MON% (%)	1.7 ± 0.4	2.3 ± 0.6**	2.7 ± 0.7**	2.7 ± 0.5**
PLT (× 103/µL)	748 ± 42	706 ± 42*	676 ± 99**	617 ± 119**
APTT (sec)	18.0 ± 1.8	18.5 ± 2.1	16.7 ± 1.9	19.4 ± 3.3
PT (sec)	10.5 ± 0.5	10.7 ± 0.4	12.6 ± 1.4**	10.6 ± 0.3

Differences among ages are expressed as p<0.05,
p<0.01 based on the result of Dunnett’s or Dunn’s test.
APTT and PT were examined in 23 males in the 52-week study.
RBC, red blood cell; HGB, hemoglobin; HCT, hematocrit; MCV, mean cell volume; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; RETA, reticulocyte count; RET%, reticulocyte percentage; WBC, white blood cell; LYMA, lymphocyte count; NEUA, neutrophil count; EOSA, eosinophil count; BASA, basophil count; MONA, monocyte count; LYM%, lymphocyte percentage; NEU%, neutrophil percentage; EOS%, eosinophil percentage; BAS%, basophil percentage; MON%, monocyte percentage; PLT, platelet; APTT, activated partial thromboplastin time; PT, prothrombin time.