Table 9. Summary of histopathological findings in rats inhaling diethylbenzene for 90 days

Sex			Male			Female
Group		Control	Middle (80 ppm)	High (160 ppm)	Control	Low (40 ppm)	High (160 ppm)
n		10	1	10	10	2	10
Organ
Heart
Cardiomyopathy	1a	3	-	1	0	-	0
	Total	3	-	1	0	-	0
Liver
Infiltration, mononuclear cell	1a	0	-	1	1	-	1
	Total	0	-	1	1	-	1
Lung
Aggregates, alveolar macrophage	1	5	-	3	2	0	1
	2a	0	-	2	1	1	0
	Total	5	-	5	3	1	1
Crystals, hematoidin	1	1	-	1	0	0	0
	Total	1	-	1	0	0	0
Hyperplasia, bronchiolo-alveolar	1a	1	-	2	0	0	0
	Total	1	-		0	0	0
Infiltration, mononuclear cell	1a	0	-	1	0	0	0
	Total	0	-	1	0	0	0
Nasal cavity
Hyperplasia, mucous cell	1	1	-	2	0	-	0
	Total	1	-	2	0	-	0
Pancreas
Atrophy, acinar cell	1	1	-	1	0	-	0
	2	1	-	0	0	-	0
	Total	2	-	1	0	-	0
Infiltration, mixed cell	1	0	-	0	0	-	1
	Total	0	-	0	0	-	1
Inflammation, granulomatous	1	0	-	1	0	-	0
	2	1	-	0	0	-	0
	Total	1	-	1	0	-	0
Pigmentation	1	1	-	0	0	-	0
	Total	1	-	0	0	-	0
Vacuolation, acinar cell	2	0	-	0	0	-	1
	Total	0	-	0	0	-	1
Pituitary
Cyst, pars distalis	1	0	-	1	0	-	0
	Total	0	-	1	0	-	0
Spleen
Extramedullary hematopoiesis	1	0	-	1	1	-	2
	Total	0	-	1	1	-	2
Sarcoma, NOS	Total	1	-	0	0	-	0
Testes
Dilation, seminiferous tubules	2	0	1	0	-	-	-
	Total	0	1	0	-	-	-
Thyroids
Adenoma, C-cell	Total	0	-	0	0	-	1
Ectopic tissue, thymus	1	1	-	0	0	-	0
	Total	1	-	0	0	-	0
Ultimobranchial cyst	1	2	-	3	0	-	2
	Total	2	-	3	0	-	2
Vagina
Cyst	1	-	-	-	0	1	0
	Total	-	-	-	0	1	0

Severity; 1, Minimal; 2, Mild.
n, number of animals examined; NOS, not otherwise specified; -, not applicable.