Table 4. Gross pathological findings seen in rats and dogs after single oral and dose escalating toxicity study for CPSS
| Species | Sex | Dose (mg/kg B.W.) | Remarkable organ | Gross findings | No. of animals | Type of sacrifice |
| Rat | Female | Step 1: 300 | Not remarkable | - | 0/3 | Schedule (day 14) |
| Step 2: 300 | Not remarkable | - | 0/3 | Schedule (day 14) |
| Step 3: 2,000 | Not remarkable | - | 0/3 | Schedule (day 14) |
| Step 4: 2,000 | Not remarkable | - | 0/3 | Schedule (day 14) |
| Dog | Male | 0 → 0 → 0 | Not remarkable | - | 0/1 | Schedule (day 21) |
| 500 → 1,000 → 2,000 | Not remarkable | - | 0/2 | Schedule (day 21) |
| Female | 0 → 0 → 0 | Not remarkable | - | 0/1 | Schedule (day 21) |
| 500 → 1,000 → 2,000 | Not remarkable | - | 0/2 | Schedule (day 21) |
CPSS, collagen peptide derived from skate (R. kenojei) skin; B.W., body weight; -, no abnormalities detected.