Table 1. Mortality and clinical signs of female rats in single oral toxicity study for CPSS

Step	No. of animals	Dose (mg/kg B.W.)	Clinical signs	Mortality	LD50 (mg/kg B.W.)
1	3	300	No abnormalities detected	0% (0/3)1)	> 5,000
2	3	300	No abnormalities detected	0% (0/3)
3	3	2,000	No abnormalities detected	0% (0/3)
4	3	2,000	No abnormalities detected	0% (0/3)

No. of dead animals/No. of tested animals.
CPSS, collagen peptide derived from skate (R. kenojei) skin; B.W., body weight; LD50, lethal dose for 50% kill.