Table 9. Summary of major histopathological findings in mice inhaling 1,2-dichlorobenzene for 90 days

Variable		Male				Female
Variable		Control	T1 (30 ppm)	T2 (60 ppm)	T3 (120 ppm)	Control	T1 (30 ppm)	T2 (60 ppm)	T3 (120 ppm)
N		10	10	10	10	10	10	10	10
Organ
Liver
Mineralization, dystrophic	1^a	0	0	0	3	0	0	0	0
	2^a	0	0	0	3	0	0	0	0
	3^a	0	0	0	3	0	0	0	0
	Total	0	0	0	9	0	0	0	0
Necrosis	1^a	0	0	0	1	0	0	0	0
Necrosis	Total	0	0	0	1	0	0	0	0
Pigmentation	1^a	0	0	0	8	0	0	0	0
	2^a	0	0	0	1	0	0	0	0
	Total	0	0	0	9	0	0	0	0
Infiltration, mononuclear cell	1^a	2	0	0	2	4	1	0	1
Infiltration, mononuclear cell	Total	2	0	0	2	4	1	0	1
Nasal cavity
Atrophy	1^a	0	0	0	0	0	2	1	2
	2^a	0	0	0	1	0	2	3	1
	3^a	0	0	0	0	0	1	0	2
	4^a	0	0	0	1	0	0	0	0
	Total	0	0	0	2	0	5	4	5
Dilatation, glands	2^a	0	0	0	0	0	1	4	6
	3^a	0	0	0	0	0	4	6	0
	Total	0	0	0	0	0	5	10	6
Eosinophilic globules	1^a	0	7	2	2
	2^a	0	3	3	5	0	4	1	0
	3^a	0	0	3	1	0	5	4	8
	4^a	0	0	2	2	0	1	5	1
	Total	0	10	10	10	0	10	10	9
Hyperplasia, basal cell	1^a	0	1	3	3	0	3	3	6
	2^a	0	2	2	3	0	4	3	3
	3^a	0	4	5	3	0	2	2	0
	4^a	0	3	0	1	0	1	0	0
	Total	0	10	10	10	0	10	8	9
Respiratory metaplasia	1^a	0	0	6	0	0	1	0	0
	2^a	0	3	2	1	0	3	5	0
	3^a	0	5	2	0	0	4	4	0
	4^a	0	2	0	0	0	2	1	0
	Total	0	10	10	1	0	10	10	0

Severity: 1, minimal; 2, mild; 3, moderate; 4, marked.
N, number of animals examined.