Table 7. Summary of relative organ weight data in mice inhaling 1,2-dichlorobenzene for 90 days

Organs (%) Groups (ppm)
Control T1 (30) T2 (60) T3 (120)
N (Male) 10 10 10 10
Adrenal glands 0.0154 ± 0.00325 0.0206 ± 0.00844 0.0159 ± 0.00715 0.0151 ± 0.00576
Brain 1.3817 ± 0.08392 1.5508 ± 0.10332** 1.4932 ± 0.07216* 1.4471 ± 0.07831
Epididymides 0.2767 ± 0.03049 0.3190 ± 0.02259** 0.3085 ± 0.02236* 0.3082 ± 0.03361*
Heart 0.3954 ± 0.02492 0.4073 ± 0.02729 0.4114 ± 0.02993 0.3829 ± 0.02065
Kidneys 1.3764 ± 0.09646 1.4373 ± 0.08849 1.4433 ± 0.06828 1.4020 ± 0.05840
Liver 3.9860 ± 0.43985 3.8307 ± 0.39814 3.8511 ± 0.33944 4.2722 ± 0.37117
Lung 0.1770 ± 0.02601 0.2043 ± 0.02037* 0.1860 ± 0.01117 0.1828 ± 0.02012
Spleen 0.2164 ± 0.02127 0.1869 ± 0.01562** 0.1778 ± 0.01622** 0.1926 ± 0.01693*
Testes 0.6607 ± 0.05937 0.7518 ± 0.04072** 0.7170 ± 0.04892* 0.6998 ± 0.03970
Thymus 0.0908 ± 0.00883 0.0977 ± 0.01869 0.0947 ± 0.00732 0.1009 ± 0.01809
N (Female) 10 10 10 10
Adrenal glands 0.0429 ± 0.00644 0.0430 ± 0.00756 0.0397 ± 0.00577 0.0376 ± 0.00870
Brain 1.9318 ± 0.06903 1.881 ± 0.06855 1.8806 ± 0.089614 1.8327 ± 0.05827*
Heart 0.4397 ± 0.02632 0.4150 ± 0.02610 0.4182 ± 0.02896 0.4163 ± 0.01732
Kidneys 1.2002 ± 0.04937 1.1843 ± 0.06135 1.2138 ± 0.05535 1.1980 ± 0.05764
Liver 4.1389 ± 0.33508 4.1313 ± 0.52865 4.1577 ± 0.44517 4.3813 ± 0.27266
Lung 0.2467 ± 0.04883 0.2391 ± 0.01623 0.2298 ± 0.03116 0.2203 ± 0.01530
Ovaries 0.0572 ± 0.00735 0.0479 ± 0.00782 0.0681 ± 0.04969 0.0125 ± 0.00207
Spleen 0.3611 ± 0.02628 0.2654 ± 0.03248** 0.2852 ± 0.03233** 0.2994 ± 0.02909**
Thymus 0.1423 ± 0.02518 0.1325 ± 0.03218 0.1293 ± 0.01131 0.1368 ± 0.01881
Uterus 0.6210 ± 0.16142 0.6055 ± 0.16109 0.5712 ± 0.15539 0.5870 ± 0.17213
Data are expressed as the mean ± S.D.
Dunnett’s LSD test significant at the 0.05 level.
Dunnett’s LSD test significant at the 0.01 level.
N, number of animals examined.