Table 5. Summary of blood biochemistry data in female mice inhaling 1,2-dichlorobenzene for 90 days
Parameters | Groups (ppm) |
Control | T1 (30) | T2 (60) | T3 (120) |
N | 10 | 10 | 10 | 10 |
Na (mmol/L) | 136.47 ± 1.125 | 137.08 ± 0.809 | 137.38 ± 1.023 | 137.67 ± 0.686* |
K (mmol/L) | 4.070 ± 0.1947 | 4.230 ± 0.4498 | 4.210 ± 0.2807 | 4.230 ± 0.2263 |
Cl (mmol/L) | 105.46 ± 0.757 | 104.46 ± 1.410 | 104.74 ± 0.797 | 105.80 ± 0.871 |
TP (g/dL) | 3.48 ± 0.114 | 3.42 ± 0.092 | 3.39 ± 0.099 | 3.46 ± 0.126 |
ALB (g/dL) | 3.10 ± 0.115 | 3.11 ± 0.099 | 3.07 ± 0.082 | 3.15 ± 0.108 |
CREA (mg/dL) | 0.279 ± 0.0292 | 0.299 ± 0.0321 | 0.291 ± 0.0233 | 0.291 ± 0.0242 |
BUN (mg/dL) | 23.44 ± 4.944 | 28.26 ± 0.0321 | 26.96 ± 13.219 | 21.39 ± 3.911 |
GLU (mg/dL) | 230.85 ± 39.892 | 240.55 ± 16.181 | 226.35 ± 38.649 | 251.25 ± 19.196 |
Ca (mg/dL) | 8.20 ± 0.183 | 8.40 ± 0.189 | 8.37 ± 0.134 | 8.36 ± 0.171 |
IP (mg/dL) | 8.55 ± 1.782 | 7.68 ± 1.782 | 7.70 ± 1.547 | 7.33 ± 1.067 |
TBIL (mg/dL) | 0.148 ± 0.0290 | 0.176 ± 0.0280 | 0.150 ± 0.0163 | 0.157 ± 0.0241 |
TCHO (mg/dL) | 112.13 ± 5.175 | 119.06 ± 12.402 | 114.82 ± 5.910 | 114.57 ± 8.379 |
TG (mg/dL) | 42.56 ± 20.670 | 42.34 ± 11.628 | 33.33 ± 9.648 | 41.22 ± 8.273 |
AST (IU/L) | 53.19 ± 17.043 | 50.08 ± 15.005 | 47.50 ± 11.557 | 49.24 ± 11.098 |
ALT (IU/L) | 26.54 ± 10.621 | 26.29 ± 5.926 | 26.48 ± 9.776 | 30.65 ± 9.706 |
ALP (IU/L) | 265.82 ± 23.915 | 290.98 ± 27.062 | 284.87 ± 33.157 | 275.20 ± 16.195 |
A/G ratio | 8.51 ± 1.839 | 10.38 ± 2.200 | 9.98 ± 2.198 | 10.50 ± 2.315 |
Data are expressed as the mean ± S.D.
Dunnett’s LSD test significant at the 0.05 level.
N, number of animals examined; Na, sodium; K, potassium; Cl, chloride; TP, total protein; ALB, albumin; CREA, creatinine; BUN, blood urea nitrogen; GLU, glucose; Ca, calcium; IP, inorganic phosphorus; TBIL, total bilirubin; TCHO, total cholesterol; TG, triglycerides; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; A/G ratio, albumin/globulin ratio.