| Items | Dose (mg/kg/day) | |||
|---|---|---|---|---|
| Male | Female | |||
| 0 | 2,000 | 0 | 2,000 | |
| No. of animal examined | 5 | 5 | 5 | 5 |
| Liver | ||||
| Inflammatory cell | ||||
| Minimal | 1 | 2 | 0 | 0 |
| Focal necrosis | ||||
| Minimal | 1 | 0 | 0 | 0 |
| Kidney | ||||
| Tubular cast | ||||
| Minimal | 0 | 0 | 1 | 0 |
| Tubular dilation | ||||
| Minimal | 0 | 0 | 0 | 1 |
| Interstitial inflammatory cell infiltration | ||||
| Slight | 0 | 1 | 0 | 0 |
| Brain pituitary | ||||
| Pituitary, vacuolation | ||||
| Minimal | 0 | 1 | 0 | 0 |
| Spleen | ||||
| EMH | ||||
| Minimal | 1 | 1 | 0 | 0 |
| Pancreas | ||||
| Interstitial inflammatory cell infiltration | ||||
| Minimal | 0 | 1 | 0 | 0 |