Table 6. Serum biochemical values of female rats in the 28-day repeated oral dose toxicity study of SUNACTIVE Fe-P80
| Parameter | Dose (mg/kg/day) |
| 0 | 500 | 1,000 | 2,000 |
| No. of females examined | 5 | 5 | 5 | 5 |
| AST (IU/L) | 114.8 ± 6.4 | 119.0 ± 36.2 | 125.0 ± 24.2 | 104.2 ± 20.0 |
| ALT (IU/L) | 28.8 ± 4.1 | 34.2 ± 13.0 | 29.0 ± 7.4 | 26.4 ± 4.4 |
| ALP (IU/L) | 355.2 ± 45.6 | 456.6 ± 85.6 | 351.6 ± 87.2 | 337.6 ± 47.9 |
| CPK (IU/L) | 696.6 ± 163.0 | 605.0 ± 295.7 | 966.2 ± 391.5 | 654.8 ± 337.4 |
| TBIL (mg/dL) | 0.014 ± 0.009 | 0.018 ± 0.015 | 0.006 ± 0.009 | 0.020 ± 0.035 |
| TBA (μmol/L) | 14.7 ± 6.5 | 18.0 ± 15.0 | 12.9 ± 5.4 | 14.9 ± 3.5 |
| Glucose (mg/dL) | 134.0 ± 23.6 | 134.0 ± 16.8 | 141.6 ± 13.0 | 138.8 ± 19.7 |
| TCHO (mg/dL) | 65.6 ± 3.6 | 70.0 ± 9.7 | 81.0 ± 20.7 | 81.0 ± 11.4 |
| Triglyceride (mg/dL) | 9.6 ± 1.7 | 13.4 ± 5.5 | 12.2 ± 2.0 | 12.8 ± 7.9 |
| TP (g/dL) | 6.0 ± 0.1 | 5.8 ± 0.2 | 5.9 ± 0.2 | 6.1 ± 0.5 |
| Albumin (g/dL) | 3.8 ± 0.1 | 3.7 ± 0.2 | 3.8 ± 0.1 | 4.0 ± 0.4 |
| A/G (ratio) | 1.8 ± 0.2 | 1.8 ± 0.2 | 1.8 ± 0.0 | 1.9 ± 0.2 |
| BUN (mg/dL) | 16.6 ± 2.4 | 18.9 ± 3.4 | 17.9 ± 2.4 | 15.9 ± 2.0 |
| Creatinine (mg/dL) | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.0 | 0.5 ± 0.0 |
| IP (mg/dL) | 7.4 ± 0.9 | 7.8 ± 1.0 | 7.2 ± 0.9 | 6.0 ± 1.0 |
| GGT (IU/L) | 0.3 ± 0.4 | 0.2 ± 0.4 | 0.0 ± 0.1 | 0.1 ± 0.1 |
| Ca++ (mg/dL) | 9.3 ± 0.1 | 9.3 ± 0.2 | 9.4 ± 0.3 | 9.3 ± 0.3 |
| Na+ (mmol/L) | 142.8 ± 1.1 | 144.3 ± 1.1 | 143.4 ± 0.9 | 143.7 ± 2.2 |
| K+ (mmol/L) | 4.3 ± 0.3 | 4.2 ± 0.0 | 4.2 ± 0.3 | 4.2 ± 0.3 |
| Cl– (mmol/L) | 106.1 ± 1.4 | 107.3 ± 1.4 | 105.3 ± 0.7 | 107.7 ± 1.6 |
| Fe-L (μg/dL) | 202.3 ± 60.2 | 225.3 ± 55.3 | 193.2 ± 95.1 | 188.8 ± 48.5 |
Values are presented as means ± S.D.
AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; CPK, creatine phosphokinase; TBIL, total bilirubin; TBA, total bile acid; TCHO, total cholesterol; TP, total protein; A/G, albumin/globulin; BUN, blood urea nitrogen; IP, inorganic phosphorus; GGT, gamma glutamyl transpeptidase; Fe-L, ferritin.