Table 5. Serum biochemical values of male rats in the 28-day repeated oral dose toxicity study of SUNACTIVE Fe-P80
| Parameter | Dose (mg/kg/day) |
| 0 | 500 | 1,000 | 2,000 |
| No. of males examined | 5 | 5 | 5 | 5 |
| AST (IU/L) | 124.2 ± 42.3 | 111.4 ± 30.3 | 96.0 ± 22.2 | 115.6 ± 39.0 |
| ALT (IU/L) | 30.6 ± 5.1 | 31.8 ± 4.7 | 29.4 ± 2.5 | 30.2 ± 5.4 |
| ALP (IU/L) | 555.6 ± 69.1 | 642.6 ± 130.0 | 576.8 ± 72.9 | 508.6 ± 82.0 |
| CPK (IU/L) | 883.6 ± 599.6 | 644.8 ± 422.8 | 464.8 ± 286.7 | 739.2 ± 463.7 |
| TBIL (mg/dL) | 0.020 ± 0.015 | 0.016 ± 0.004 | 0.019 ± 0.012 | 0.022 ± 0.049 |
| TBA (μmol/L) | 12.6 ± 3.5 | 15.4 ± 5.0 | 14.6 ± 11.4 | 14.1 ± 5.9 |
| Glucose (mg/dL) | 144.2 ± 31.4 | 150.2 ± 48.5 | 147.2 ± 23.5 | 150.8 ± 21.2 |
| TCHO (mg/dL) | 67.6 ± 9.5 | 54.4 ± 11.3 | 59.2 ± 24.7 | 62.4 ± 7.7 |
| Triglyceride (mg/dL) | 38.4 ± 9.3 | 25.6 ± 4.5 | 17.0 ± 6.7* | 30.4 ± 9.3 |
| TP (g/dL) | 5.6 ± 0.2 | 5.8 ± 0.1 | 6.0 ± 0.4 | 5.9 ± 0.1 |
| Albumin (g/dL) | 3.6 ± 0.1 | 3.7 ± 0.0 | 3.7 ± 0.2 | 3.7 ± 0.1 |
| A/G (ratio) | 1.7 ± 0.1 | 1.7 ± 0.1 | 1.7 ± 0.1 | 1.7 ± 0.1 |
| BUN (mg/dL) | 13.0 ± 1.2 | 13.5 ± 2.4 | 13.9 ± 3.0 | 13.8 ± 1.5 |
| Creatinine (mg/dL) | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.0 |
| IP (mg/dL) | 8.2 ± 0.6 | 9.1 ± 1.7 | 9.1 ± 2.4 | 8.2 ± 0.5 |
| GGT (IU/L) | 0.4 ± 0.2 | 0.7 ± 1.1 | 0.5 ± 0.4 | 0.3 ± 0.2 |
| Ca++ (mg/dL) | 8.7 ± 0.8 | 9.4 ± 0.5 | 9.4 ± 0.5 | 9.7 ± 0.3 |
| Na+ (mmol/L) | 145.3 ± 0.4 | 145.2 ± 1.4 | 145.5 ± 0.4 | 144.6 ± 1.2 |
| K+ (mmol/L) | 4.8 ± 0.4 | 4.9 ± 0.4 | 4.9 ± 1.1 | 4.9 ± 0.4 |
| Cl– (mmol/L) | 106.1 ± 1.0 | 105.7 ± 1.6 | 107.2 ± 2.5 | 105.4 ± 1.5 |
| Fe-L (μg/dL) | 98.6 ± 11.7 | 131.2 ± 100.5 | 93.5 ± 9.6 | 95.3 ± 15.5 |
Values are presented as means ± S.D.
Significantly different from the vehicle control group at p<0.05.
AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; CPK, creatine phosphokinase; TBIL, total bilirubin; TBA, total bile acid; TCHO, total cholesterol; TP, total protein; A/G, albumin/globulin; BUN, blood urea nitrogen; IP, inorganic phosphorus; GGT, gamma glutamyl transpeptidase; Fe-L, ferritin.