Table 1. Major platelet granule contents involved in regeneration

Platelet granule contents	Role	Ref
Platelet-derived growth factor (PDGF)	Upregulate VEGFPromote endothelial cell survival and proliferationReinforce the granulation tissueProduce inflammation in early wound healing	[16, 18, 20]
Vascular endothelium growth factor (VEGF)	Accelerate re-epithelialization and wound closureGranulation tissue formationPromote endothelial cell survival and proliferation	[11, 16, 17]
Fibroblast growth factor (FGF)	Upregulate VEGFAccelerate re-epithelialization	[17]
Transforming growth factor- β1 (TGF-β1)	Reinforce the granulation tissueProduce inflammation in early wound healing	[18, 20]
Matrix metalloproteinase (MMP)	Contribute to debris clearanceReconstruct extracellular matrix	[19]
Epidermal growth factor (EGF)	Accelerate keratinocyte migration, fibroblast and formation of granulation tissue.	[21]
Insulin-like growth factor (IGF)	Stimulate proliferation and migration of fibroblast, osteocyte, chondrocyte, and myocyte	[22, 23]
Hepatocyte growth factor (HGF)	Stimulate epithelial and endothelial cell migration	[12]
Connective tissue growth factor (CTGF)	Promote angiogenesis, cartilage regeneration, fibrosis and platelet adhesion	[15]
Platelet factor 4 (PF4)	Chemoattract monocytes, neutrophils, and fibroblasts into wounds	[24, 25]
Angiopoietin	Chemoattract pericytes	[13]
Stromal cell-derived factor (SCGF)	Chemoattract endothelial precursors	[14]