Table 1. Effect of ACG on MCAO/R-induced behavioral deficits in rats
Group | Dose (mg/kg) | Neurological score | Rotarod duration (s) |
Vehicle | - | 2.5 ± 0.3 | 54.5 ± 6.8 |
ACG | 10 | 1.8 ± 0.2 | 89.7 ± 12.7 |
ACG | 25 | 1.2 ± 0.2** | 122.2 ± 18.3* |
ACG | 50 | 1.2 ± 0.2** | 141.2 ± 10.5** |
After MCAO/R, neurological status and rotarod duration of the animals used in Fig. 1 were evaluated. Five categories of neurological finding were scored: 0, no apparent deficits; 1, contralateral forelimb flection; 2, decreased grip of contralateral forelimb; 3, contralateral circling of pulled by tail; 4, spontaneous contralateral circling.
Values are expressed as mean ± S.E.M. obtained from 5 to 6 rats.
p<0.05 vs. vehicle,
p<0.01 vs. vehicle.
MCAO/R, middle cerebral artery occlusion/reperfusion.