Table 4. Plasma histamine and immunoglobulin E concentrations of the study dogs before and after subcutaneous administration of vitamin K₁

	Before subcutaneous vitamin K₁ injection		After subcutaneous vitamin K₁ injection		95% CI for the difference between medians	p-value
	Median	Range	Median	Range	95% CI for the difference between medians	p-value
Plasma histamine concentration (¼g/L)	0.72	0.49–2.14	3.00	0.51–2.29	0.02–0.40	0.0005
Plasma immunoglobulin E concentration (¼g/L)	3.31	2.27–8.13	4.88	2.35–12.4	0.01–2.99	0.0490

CI, confidence interval.