Table 2. Inhibitory effects of ACG on Aβ (25–35)-induced reductions in GSH levels and increases in TBARS levels in mouse brain

Group Dose (mg/kg) GSH (nmol/mg protein) TBARS (nmol/mg protein)
Sham - 9.6 ± 0.4 0.17 ± 0.02
Aβ (25–35) 15 nmol 7.9 ± 0.2## 0.23 ± 0.02#
+ ACG 10 8.9 ± 0.6 0.19 ± 0.01
+ ACG 25 9.1 ± 0.3* 0.17 ± 0.01**
+ ACG 50 10.5 ± 0.6** 0.16 ± 0.01**
GSH and TBARS levels were measured after the passive avoidance test retention trial. Values are expressed as means ± S.E.M. (n = 6 mice/group).
p<0.05
p<0.01 vs. sham control;
p<0.05
p<0.01 vs. 15 nmol Aβ (25–35) control.