Values | Reference intervals | Healthy dogs (n = 6) | |
---|---|---|---|

Glucose (mg/dL)^{*} | 504 | 65–118 | 106–113^{††} |

Insulin (µIU/mL)^{**} | 14.0 | 5.2–41.5 | 5.5–9.6^{††} |

HOMA_{insulin sensitivity}^{†} | 23.5 | NA | 76.2–133.9^{††} |

HOMA_{β-cell function}^{†} | 8.2 | NA | 48.2–70.5^{††} |

Insulin levels were determined using a chemiluminescent immunoassay-based autoanalyzer (Immulite 1000; DPC, Los Angeles, CA, USA).

HOMA indices were calculated with nonlinear formulas in HOMA calculator (HOMA Calculator Version 2.2.3; Diabetes Trial Unit, University of Oxford, Oxford, UK) validated in dogs. In some cases in which glucose or insulin concentrations exceeded value allowed by the HOMA calculator, the mathematical formula was used to calculate the HOMA indices:

HOMA

HOMA

with glucose and insulin concentrations expressed in mM and µIU/mL, respectively.

Ranges of each values in age-matched control dogs (n = 6).

HOMA, homeostatic model assessment; NA, not applicable.