Table 1. Comparison of organ biodistribution in HER2-positive JIMT-1 cell-bearing mice and healthy marmosets at day 1 after administration of 125I-LCB14-0110. Radioactivity is expressed as % ID/tissue
Organs | Tumor bearing mice | Healthy marmoset |
% ID/tissue | Relative organ weight (%) | % ID/tissue | Relative organ weight (%) |
Blood | 31.770 ± 10.869 | 7* | 17.743 ± 8.648 | 7* |
Liver | 3.809 ± 1.211 | 5.68 ± 0.40 | 5.939 ± 2.838 | 3.15 ± 0.17 |
Spleen | 0.466 ± 0.020 | 0.58 ± 0.10 | 0.729 ± 0.090 | 0.07 ± 0.01 |
Heart | 0.568 ± 0.108 | 0.48 ± 0.05 | 0.523 ± 0.273 | 0.51 ± 0.01 |
Kidneys | 1.195 ± 0.408 | 1.21 ± 0.08 | 0.784 ± 0.295 | 0.55 ± 0.08 |
Lung | 1.111 ± 0.297 | 0.63 ± 0.04 | 1.154 ± 0.548 | 0.43 ± 0.08 |
Stomach | 0.765 ± 0.538 | 2.18 ± 0.70 | 0.170 ± 0.006 | 0.36 ± 0.01 |
Intestine | 3.513 ± 0.905 | 11.89 ± 0.87 | 2.650 ± 0.322 | 2.60 ± 0.79 |
Blood volume was estimated 7% of total body weight for calculation.