Table 2. Summary of serum biochemical values of SD rats orally treated with water extract of Artemisia annua in 13-week repeated dose toxicity study

Group summary of clinical chemistry1) (period: 13 weeks)
Items Dosage (mg/5mL/kg B.W.)
Male Female
0 (Control) 1,000 (WEAA) 0 (Control) 1,000 (WEAA)
Urea nitrogen (mg/dL) 14.2 ± 2.13 16.1 ± 4.30 14.8 ± 3.42 15.0 ± 3.02
Cholesterol (mg/dL) 86 ± 19.7 104 ± 12.2 97 ± 18.2 91 ± 20.6
Total protein (g/dL) 6.3 ± 1.07 7.0 ± 1.00 6.9 ± 0.65 6.8 ± 0.42
Albumin (g/dL) 2.4 ± 0.44 2.7 ± 0.43 3.1 ± 0.32 3.0 ± 0.23
Total bilirubin (mg/dL) 0.08 ± 0.02 0.06 ± 0.03 0.09 ± 0.02 0.08 ± 0.02
Alkaline phosphatase (IU/L) 402 ± 79.2 370 ± 95.0 214 ± 119.2 204 ± 65.6
Aspartate aminotransferase (IU/L) 100 ± 24.1 119 ± 34.6 96 ± 14.3 98 ± 18.2
Alanine aminotransferase (IU/L) 40 ± 13.2 41 ± 8.9 36 ± 6.6 34 ± 5.6
γ-Glutamyl transferase (IU/L) 0 ± 0.3 0 ± 0.3 0 ± 0.3 0 ± 0.0
Creatinine (mg/dL) 0.53 ± 0.101 0.56 ± 0.134 0.61 ± 0.053 0.60 ± 0.052
Triglycerides (mg/dL) 83 ± 38.6 96 ± 58.1 64 ± 36.9 40 ± 18.7
Glucose (mg/L) 150 ± 29.2 177 ± 38.0 166 ± 16.8 174 ± 30.6
A/G ratio 0.6 ± 0.04 0.6 ± 0.06 0.8 ± 0.03 0.8 ± 0.08
Potassium (mmol/L) 4.8 ± 0.66 5.7 ± 0.93 4.5 ± 0.42 4.4 ± 0.47
Chloride (mEg/L) 111 ± 17.1 127 ± 24.5 114 ± 10.3 113 ± 6.6
Sodium (mmol/L) 153 ± 19.6 171 ± 26.7 155 ± 11.4 153 ± 7.0
Calcium (mg/dL) 10.3 ± 1.36 11.8 ± 1.83 10.8 ± 0.87 10.5 ± 0.55
Phosphorous (mg/dL) 7.0 ± 0.95 8.0 ± 1.11 6.3 ± 0.88 5.9 ± 0.49
All values are mean ± S.D. (N [number of animals] = 10).
No statistical significance observed.
WEAA, water extract of Artemisia annua.