Table 1. Summary of hematological values of SD rats orally treated with water extract of Artemisia annua in 13-week repeated dose toxicity study

Items	Group summary of hematological analysis (period: 13 weeks)
	Dosage (mg/5 mL/kg B.W.)
	Male1)		Female
	0 (Control)	1,000 (WEAA)	0 (Control)	1,000 (WEAA)
Leukocytes (103/mm3)	9.09 ± 1.886	8.52 ± 1.120	6.81 ± 1.936	6.61 ± 2.128a
Erythrocytes (106/mm3)	8.41 ± 0.595	8.41 ± 0.328	7.83 ± 0.169	7.50 ± 0.307
Hemoglobin (g/dL)	14.3 ± 0.84	14.4 ± 0.57	14.2 ± 0.41	13.8 ± 0.42
Hematocrit (%)	46.9 ± 2.55	46.9 ± 1.81	44.9 ± 1.44	43.6 ± 1.63
Platelets (103/mm3)	881 ± 249.7	962 ± 94.2	984 ± 85.7	970 ± 75.4
MCV (fL)	55.8 ± 1.97	55.8 ± 1.23	57.3 ± 1.54	58.2 ± 1.15
MCH (pg)	17.0 ± 0.79	17.1 ± 0.44	18.2 ± 0.55	18.4 ± 0.43
MCHC (g/dL)	30.4 ± 0.63	30.6 ± 0.40	31.6 ± 0.55	31.6 ± 0.40b
Neutrophils (%)	14.5 ± 5.60	13.8 ± 5.66	8.6 ± 2.73	12.8 ± 4.95
Eosinophils (%)	1.1 ± 0.53	1.0 ± 0.35	1.4 ± 0.52	1.0 ± 0.67
Basophils (%)	0.4 ± 0.17	0.3 ± 0.09	0.3 ± 0.13	0.3 ± 0.11
Lymphocytes (%)	81.1 ± 6.23	81.8 ± 6.17	86.6 ± 2.64	82.9 ± 5.64
Monocytes (%)	2.2 ± 0.84	2.5 ± 0.75	2.2 ± 0.43	2.4 ± 0.60
Reticulocyte (%)	2.69 ± 0.476	2.50 ± 0.329	2.33 ± 0.468	2.46 ± 0.531

All values are mean ± S.D. (N [number of animals] = 10).
No statistical significance observed.
Significantly different from the control group; p<0.01.
Significantly different from the control group; p<0.05.
WEAA, water extract of .Artemisia annua.