Table 1. Time difference comparison of various indices in cats with cardiovascular-renal axis disorder (CvRD)

Index	Day 0	Day 30	Day 60	Day 90	p-value
BW (kg)	4.7 ± 1.01	4.6 ± 1.21	4.8 ± 1.18	4.8 ± 1.08	0.991
SBP (mmHg)	150 ± 16.9	145 ± 11.8	160 ± 13.0	140 ± 12.6	0.293
Cell blood count
HCT (%)	46.3 ± 6.77	44.1 ± 6.10	46.1 ± 6.73	44.2 ± 7.97	0.826
RBC (106 μL)	9.5 ± 1.68	9.6 ± 1.70	9.4 ± 1.96	9.0 ± 2.12	0.989
WBC (103 μL)	8.4 ± 4.79	8.0 ± 4.21	7.2 ± 5.68	6.3 ± 6.94	0.892
Serum chemistry
Albumin (g/dL)	4.0 ± 0.70	4.3 ± 0.62	3.8 ± 0.34	3.9 ± 0.44	0.715
ALKP (g/dL)	28 ± 9.4	20 ± 12.0	26 ± 8.9	26 ± 9.2	0.303
ALT (g/dL)	56.5 ± 56.4	64.5 ± 38.4	61 ± 75.2	62 ± 41.4	0.979
BUN (g/dL)	24 ± 7.8	27 ± 7.6	23 ± 7.5	22 ± 8.4	0.653
Crea (g/dL)	2.2 ± 0.64	2.0 ± 0.59	1.8 ± 0.64	2.0 ± 0.73	0.875
TP (g/dL)	7.9 ± 0.66	7.6 ± 0.52	7.8 ± 0.66	7.7 ± 0.45	0.836
Urine
pH	6.75 ± 0.7	6.5 ± 0.6	6.5 ± 0.6	6.5 ± 0.4	0.604
UP/C	0.39 ± 0.255	0.29 ± 0.056	0.28 ± 0.040	0.25 ± 0.128	<0.001
SG	1.017 ± 0.0098	1.022 ± 0.0110	1.021 ± 0.0175	1.020 ± 0.0143	0.912
Echocardiography
LA diameter (mm)	17.9 ± 1.6	17.4 ± 1.8	16.1 ± 1.6	15.7 ± 1.7	0.011
IVSDd (mm)	7.49 ± 0.95	7.36 ± 1.14	7.30 ± 1.11	6.96 ± 0.13	0.381

All data expressed with the mean value (± SD).
SBP, systolic blood pressure; HCT, hematocrit; RBC, red blood cell; WBC, white blood cell ALKP, alkaline phosphatase; ALT, alanine aminotransferase; BUN, blood urea nitrogen; Crea, creatinine; TP, total protein; UP/C, urine protein to creatinine ratio; SG, specific gravity; LA, left atrium; IVSDd, interventricular septum end-diastolic diameter.