| (A) Biological process during GO ontology analysis of selectin genes | |||
|---|---|---|---|
| GO-term | Description | Count in gene set | False discovery rate |
| GO:0032802 | Low-density lipoprotein particle receptor catabolic process | 5 of 10 | 1.01e-10 |
| GO:0072583 | Clathrin-dependent endocytosis | 5 of 24 | 1.32e-09 |
| GO:0034383 | Low-density lipoprotein particle clearance | 5 of 24 | 1.32e-09 |
| GO:0050690 | Regulation of defense response to virus by virus | 5 of 30 | 1.80e-09 |
| GO:0043112 | Receptor metabolic process | 6 of 95 | 2.42e-09 |
| (B) Molecular function during GO ontology analysis of selectin genes | |||
|---|---|---|---|
| GO-term | Description | Count ingene set | False discovery rate |
| GO:0050839 | Cell adhesion molecule binding | 4 of 200 | 0.00032 |
| GO:0044877 | Protein-containing complex binding | 6 of 968 | 0.00032 |
| GO:0035615 | Clathrin adaptor activity | 2 of 8 | 0.00032 |
| GO:0030369 | ICAM-3 receptor activity | 2 of 3 | 0.00032 |
| GO:0030276 | Clathrin binding | 3 of 63 | 0.00032 |
| (C) Cellular component during GO ontology analysis of selectin genes | |||
|---|---|---|---|
| GO-term | Description | Count in gene set | False discovery rate |
| GO:0030122 | AP-2 adaptor complex | 5 of 8 | 9.86e-12 |
| GO:0036020 | Endolysosome membrane | 5 of 15 | 2.96e-11 |
| GO:0098797 | Plasma membrane protein complex | 9 of 502 | 9.77e-11 |
| GO:0030659 | Cytoplasmic vesicle membrane | 9 of 724 | 1.03e-09 |
| GO:0030136 | Clathrin-coated vesicle | 6 of 172 | 7.10e-09 |
| (D) KEGG pathways of selectin gene | |||
|---|---|---|---|
| Pathway | Description | Count in gene set | False discovery rate |
| hsa05150 | Staphylococcus aureus infection | 5 of 51 | 4.95e-09 |
| hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 5 of 47 | 4.95e-09 |
| hsa04721 | Synaptic vesicle cycle | 5 of 61 | 4.95e-09 |
| hsa04514 | Cell adhesion molecules (CAMs) | 6 of 139 | 4.95e-09 |
| hsa05144 | Malaria | 4 of 47 | 2.07e-07 |
| (E) Reactome pathways of selectin genes | |||
|---|---|---|---|
| Pathway | Description | Count in gene set | False discovery rate |
| hsa182218 | Nef mediated CD8 Down-regulation | 5 of 7 | 3.09e-12 |
| hsa167590 | Nef mediated CD4 Down-regulation | 5 of 9 | 4.93e-12 |
| has8866427 | VLDLR internalisation and degradation | 5 of 12 | 1.02e-11 |
| hsa5140745 | WNT5A-dependent internalization of FZD2,FZD5, and ROR2 | 5 of 13 | 1.05e-11 |
| hsa177504 | Retrograde neurotrophin signaling | 5 of 14 | 1.14e-11 |