Table 2. Function of selectin genes

(A) Biological process during GO ontology analysis of selectin genes
GO-term Description Count in gene set False discovery rate
GO:0032802 Low-density lipoprotein particle receptor catabolic process 5 of 10 1.01e-10
GO:0072583 Clathrin-dependent endocytosis 5 of 24 1.32e-09
GO:0034383 Low-density lipoprotein particle clearance 5 of 24 1.32e-09
GO:0050690 Regulation of defense response to virus by virus 5 of 30 1.80e-09
GO:0043112 Receptor metabolic process 6 of 95 2.42e-09
(B) Molecular function during GO ontology analysis of selectin genes
GO-term Description Count ingene set False discovery rate
GO:0050839 Cell adhesion molecule binding 4 of 200 0.00032
GO:0044877 Protein-containing complex binding 6 of 968 0.00032
GO:0035615 Clathrin adaptor activity 2 of 8 0.00032
GO:0030369 ICAM-3 receptor activity 2 of 3 0.00032
GO:0030276 Clathrin binding 3 of 63 0.00032
(C) Cellular component during GO ontology analysis of selectin genes
GO-term Description Count in gene set False discovery rate
GO:0030122 AP-2 adaptor complex 5 of 8 9.86e-12
GO:0036020 Endolysosome membrane 5 of 15 2.96e-11
GO:0098797 Plasma membrane protein complex 9 of 502 9.77e-11
GO:0030659 Cytoplasmic vesicle membrane 9 of 724 1.03e-09
GO:0030136 Clathrin-coated vesicle 6 of 172 7.10e-09
(D) KEGG pathways of selectin gene
Pathway Description Count in gene set False discovery rate
hsa05150 Staphylococcus aureus infection 5 of 51 4.95e-09
hsa04961 Endocrine and other factor-regulated calcium reabsorption 5 of 47 4.95e-09
hsa04721 Synaptic vesicle cycle 5 of 61 4.95e-09
hsa04514 Cell adhesion molecules (CAMs) 6 of 139 4.95e-09
hsa05144 Malaria 4 of 47 2.07e-07
(E) Reactome pathways of selectin genes
Pathway Description Count in gene set False discovery rate
hsa182218 Nef mediated CD8 Down-regulation 5 of 7 3.09e-12
hsa167590 Nef mediated CD4 Down-regulation 5 of 9 4.93e-12
has8866427 VLDLR internalisation and degradation 5 of 12 1.02e-11
hsa5140745 WNT5A-dependent internalization of FZD2,FZD5, and ROR2 5 of 13 1.05e-11
hsa177504 Retrograde neurotrophin signaling 5 of 14 1.14e-11