Table 3
Scaled pharmacokinetic parameters for human based on species-invariant time methods

Parameter		Equivalent time	Kallynochrons	Apolysichrons	Dienetichrons
CLt	(mL/min/kg)	36.3	42.1	34.7	17.0
Vdss	(L/kg)	19.2	18.2	19.4	15.4
r2		0.948	0.954	0.957	0.931

The plasma concentration time curves of four animal species were normalized based on the time transformations. The parameters for a 70 kg human were calculated from the curves using non-compartmental analysis.