Table 2
Allometric equations, coefficients and scaled human pharmacokinetic parameters for a 70 kg human generated using simple or MLP-corrected allometry based on data from mice, rats, rabbits and dogs

Parameter		Allometric equation	Coefficient ( 2) *	Scaled human value
CLt	(mL/min/kg)	y = 45.9 W0.845	0.995	24.1 †
CLSt × MLP	(mL/min/kg)	y = 31.2 W1.14	0.999	6.99 ‡
Vdss	(mL/kg)	y = 10140 W0.865	0.968	5720 †

Values from linear regression analysis of the parameter body weight plots on a log log scale (Fig. 3).
Values from simple allometry.
Value from MLP-corrected allometry. The parameter was calculated as the human CLt × MLP divided by the human MLP of 93.4 years [14].