Table 1
Pharmacokinetic parameters of HAMX after i.v. bolus administration to mice, rats, rabbits and dogs at the dose of 10 mg/kg, 10 mg/kg, 5 mg/kg and 2.5 mg/kg, respectively*

Parameter		Mouse	Rat	Rabbit	Dog
Brain weight	(BrW, g)	0.36	1.80	14.0	80.0
Body Weight	(W, kg)	0.0251 ± 0.0021	0.239 ± 0.005	2.34 ± 0.09	10.0 ± 0.1
CLt	(mL/min/kg)	73.7. ± 5.30	64.0 ± 8.30	47.2 ± 6.50	27.1 ± 1.23
Vdss	(L/kg)	13.8 ± 2.79	13.6 ± 1.39	15.2 ± 3.61	0.856 ± 0.297

Each value represents the mean S.E. of three different experiments.