Table 2
Pharmacokinetic parameters of ferulic acid following i.v. bolus administration at the dose of 2 and 10 mg/kg in rats*

Parameter		Dose
		2 mg/kg	10mg/kg
		A	(μg/mL)	12.1 ± 0.89	61.3 ± 2.96
B	(μg/mL)	2.75 ± 0.263	16.6 ± 2.04
α	(min-1)	0.633 ± 0.022	0.501 ± 0.026
β	(min-1)	0.154 ± 0.009	0.103 ± 0.002
k12	(min-1)	0.892 ± 0.055	0.474 ± 0.033
k21	(min-1)	0.406 ± 0.013	0.296 ± 0.002
kel	(min-1)	0.686 ± 0.016	0.316 ± 0.012
t1/2,α	(min)	1.10 ± 0.043	1.39 ± 0.071†
t1/2,β	(min)	5.02 ± 0.029	7.01 ± 0.203‡
AUC	(μg·min·mL-1)	37.1 ± 1.36	284 ± 28.1‡
MRT	(min)	4.02 ± 0.203	6.31 ± 0.121‡
Vdss	(mL/kg)	218 ± 19.2	231 ± 28.1
CLt	(mL/min)	54.6 ± 1.97	36.3 ± 4.01‡

Each value represents the mean ± S.E. of three rats.
Significantly different from the 2 mg/kg dose (P<0.05).
Significantly different from the 2 mg/kg dose (P<0.01).