Table 5.
Changes in numbers of inflammatory cells, fibroblasts (fibrocytes), and micro-vessels in granulation tissues at 20 days after application with re-epithelialization

Histomorphometry Control Madecassol™ 100 mg/kg β-glucan-applied groups
10 mg/kg 50 mg/kg 100 mg/kg
Cell counts (N/mm2)
PMNs1) 98.60 ± 26.72 58.90 ± 14.40* 40.60 ± 12.52* 24.00 ± 8.82* 16.10 ± 6.82*
Macrophages 33.30 ± 9.21 23.80 ± 8.95** 20.90 ± 5.32* 10.30 ± 3.06* 8.00 ± 2.31*
Lymphocytes 40.30 ± 9.25 28.10 ± 10.91** 26.80 ± 12.53** 20.60 ± 4.62* 17.80 ± 8.13*
Fibroblasts 32.50 ± 10.86 76.00 ± 23.84* 63.10 ± 14.18* 102.80 ± 20.81* 125.20 ± 35.70*

Angiogenesis (N/mm2)
Micro-vessels 67.30 ± 21.31 68.70 ± 26.30 90.50 ± 25.29 107.00 ± 25.63* 109.20 ± 17.30*
Re-epithelialization (%) 27.18 ± 10.64 46.67 ± 10.56* 30.22 ± 8.42 69.77 ± 12.39* 80.18 ± 11.49*
n=10; (Mean ± S.D.);
Polymorphonuclear leukocytes; *p<0.01 and **p<0.05 compared to that of control by MW test.