Table 1.
Effect of green tea (GT) or epigallocatechin gallate (EGCG) on gamma-radiation-induced histological changes of dentate gyrus
Groups | TUNEL | Ki-67 | Dcx |
NC | 0 | 9.57 ± 0.64 | 46.86 ± 3.04 |
RC (2.0 Gy) | 18.50 ± 1.60 | 2.86 ± 0.61 | 19.57 ± 2.10 |
GTa + R | 12.25 ± 1.45* | 3.50 ± 0.65 | 28.50 ± 2.39* |
GTb + R | 9.00 ± 2.42* | 3.67 ± 1.04 | 20.33 ± 2.35 |
EGCGc + R | 12.50 ± 1.50* | 2.75 ± 0.25 | 25.75 ± 2.13 |
The ICR mice (n=4) were irradiated with gamma-rays (2.0 Gy) and were autopsied 12 hours later.
Values are expressed as mean ± S.E.
GT (50 mg/kg of body weight) was given i.p. at 36 and 12 hours before irradiation, and 30 minutes after irradiation.
GT (250 mg/kg of body weight/day) was given p.o. for 7 days before autopsy.
EGCG (25 mg/kg of body weight) was given i.p. at 36 and 12 hours before irradiation, and 30 minutes after irradiation.
Indicates a significant difference at P<0.05 compared with corresponding radiation control group.