Table 2.
Effect of matrigel-based HA/PCL scaffold with osteogenic, angiogenic factors and mesenchymal stem cell on bone volume and bone mineral density in a rat segmental defect model at 8 weeks after surgery
Group | Bone Volume (%) | Bone mineral density (g/mm3) |
Control | 14.918 ± 2.710 | 0.201 ± 0.115 |
Matrigel | 26.760 ± 1.493 | 0.264 ± 0.023 |
M + B | 26.529 ± 2.255 | 0.196 ± 0.013 |
M + B + V | 28.800 ± 6.436* | 0.260 ± 0.043 |
MSC | 30.790 ± 5.954* | 0.235 ± 0.058 |
P<0.05 as compared with the Control group.
Values are expressed in mean ± S.D. (n=6).
Control=no graft with 5 mm femoral segmental defect; Matrigel=grafting of matrigel based HA/PCL scaffold; M + B=grafting of matrigel based HA/PCL scaffold with BMP-2; M + B + V=grafting of matrigel based HA/PCL scaffold with BMP-2 and VEGF, MSC=grafting of matrigel based HA/PCL scaffold with BMP-2, VEGF and mesenchymal stem cell.