Table 1.
Effect of matrigel-based HA/PCL scaffold with osteogenic, angiogenic factors and mesenchymal stem cell on bone volume and bone mineral density in a rat segmental defect model at 4 weeks after surgery

Group Bone Volume (%) Bone mineral density (g/mm3)
Control 12.646 ± 2.629 0.070 ± 0.020
Matrigel 21.159 ± 3.154* 0.100 ± 0.032
M + B 24.383 ± 4.630* 0.136 ± 0.038
M + B + V 35.201 ± 3.021**.a 0.231 ± 0.030**
MSC 27.262 ± 3.479** 0.171 ± 0.045*
P<0.05 as compared with the Control group.
P<0.01 as compared with the Control group.
P<0.05 as compared with the M + B group.
Values are expressed in mean ± S.D. (n=6).
Control=no graft with 5 mm femoral segmental defect; Matrigel=grafting of matrigel based HA/PCL scaffold; M + B= grafting of matrigel based HA/PCL scaffold with BMP-2; M + B + V=grafting of matrigel based HA/PCL scaffold with BMP-2 and VEGF, MSC=grafting of matrigel based HA/PCL scaffold with BMP-2, VEGF and mesenchymal stem cell.